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ZNF512B Safeguards Genome Integrity at Regulatory Regions to Repress SASP and Inflammation

GSE206078 Homo sapiens (human) ChIP-seq / ATAC-seq (genome binding and open chromatin) 37 samples Submitted 2026/06/18 Platform GPL15520Platform GPL24676Platform GPL18573Platform GPL20301
At a glance

ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 37 samples

What it is
ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
Organism
Homo sapiens (human)
Samples
37 samples: 17 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
ZNF512B safeguards genome integrity at regulatory regions to repress the SASP and inflammationCell stem cell · 2026
Summary (written by the submitters)
Cellular senescence drives aging and disease largely through the senescence-associated secretory phenotype (SASP), yet its regulatory mechanisms remain unclear. Using a SASP reporter combined with a CRISPR-Cas9 screen targeting active regulatory elements, we identify the zinc finger protein ZNF512B as a key suppressor of SASP. ZNF512B loss induces DNA damage, activates cGAS-STING signaling, and triggers inflammatory transcriptional reprogramming.
Read the full summary ↓
In contrast, ZNF512B promotes preferential DNA repair at regulatory genomic regions, limiting SASP induction. Mechanistically, ZNF512B is rapidly recruited to DNA damage sites via distinct zinc finger domains and facilitates NuRD complex targeting to damaged chromatin, enabling precise repair. In human neuromuscular organoids, ZNF512B deficiency induces inflammation, lineage imbalance, and cytokine secretion resembling ALS-associated pathology. In vivo, ZNF512B overexpression reduces DNA damage and inflammation following acute liver injury. Together, these findings support a mechanism of preferential DNA repair that contributes to maintaining genome integrity to suppress SASP and inflammation.
Published in
ZNF512B safeguards genome integrity at regulatory regions to repress the SASP and inflammation
Sahu SK, Memczak S, Thakurela S et al. · Cell stem cell 2026 · PMID 42302791 · doi:10.1016/j.stem.2026.05.009
This dataset
Open GSE206078 in finder → Find more human RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE206078_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.

Also filed as BioProject PRJNA849015 and SRA study SRP380156. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 42302791) ↗
Study design
17 conditions, mostly in duplicate
Cas9_Screening_Library ×3 NMOs_Control ×3 NMOs_ZNF512B-KO ×3 Control_ZNF512B_C&R ×2 ZNF512B-OE_Flag_C&R ×2 Control_CHD4_C&R ×2 ZNF512B-OE_CHD4_C&R ×2 Control_RBBP4_C&R ×2 +9 more

Supports a between-group comparison across 37 samples.

How we read this: 17 replicated groups read from 37 sample titles; they account for 37 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
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