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Single cell transcriptomic profiling of caridac tissues from different degrees of septic shock mice

GSE207177 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/06/01 Platform GPL24247
Summary
Sepsis is a fatal organ dysfunction caused by the imbalance of host response caused by infection. It has the characteristics of high incidence rate, high mortality and high treatment cost. Heart is one of the most vulnerable target organs in sepsis. Sepsis can lead to myocardial depression, which is mainly manifested in the impairment of systolic function, cardiac enlargement, decreased ejection fraction and so on. Sepsis induced myocardial dysfunction (SIMD) is an important cause of septic shock and death. Therefore, using single-cell RNA sequencing to clarify the mechanisms of SIMD is of great significance to effectively prevent sepsis shock from developing into multiple organ dysfunctions (MODS) or even death.
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Direct links to NCBI, no account and no request form: the whole study as GSE207177_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA854071 and SRA study SRP384182. Searching any of these in the dataset finder brings you back here.

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