Transcriptome changes in multiple tissues of Trex1 knockout mouse after SN-011 administration
RNA-seq (gene expression) · mouse · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 24 samples: 8 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Integrative Analyses Identify a cGAS-STING Pathway-Driven Signature With Context-Dependent Roles in Systemic Lupus ErythematosusAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE207859_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA857445 and SRA study SRP385769. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 24 samples.
How we read this: 8 replicated groups read from 24 sample titles; they account for 24 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6321347 Tongue_control1 Tongue_control
- GSM6321348 Tongue_control2 Tongue_control
- GSM6321349 Tongue_control3 Tongue_control
- GSM6321350 Tongue_sn011-1 Tongue_sn011
- GSM6321351 Tongue_sn011-2 Tongue_sn011
- GSM6321352 Tongue_sn011-3 Tongue_sn011
- GSM6321353 Muscle_control1 Muscle_control
- GSM6321354 Muscle_control2 Muscle_control
- GSM6321355 Muscle_control3 Muscle_control
- GSM6321356 Muscle_sn011-1 Muscle_sn011
- GSM6321357 Muscle_sn011-2 Muscle_sn011
- GSM6321358 Muscle_sn011-3 Muscle_sn011
- GSM6321359 Stomach_control1 Stomach_control
- GSM6321360 Stomach_control2 Stomach_control
- GSM6321361 Stomach_control3 Stomach_control
- GSM6321362 Stomach_sn011-1 Stomach_sn011
- GSM6321363 Stomach_sn011-2 Stomach_sn011
- GSM6321364 Stomach_sn011-3 Stomach_sn011
- GSM6321365 Heart_control1 Heart_control
- GSM6321366 Heart_control2 Heart_control
- GSM6321367 Heart_control3 Heart_control
- GSM6321368 Heart_sn011-1 Heart_sn011
- GSM6321369 Heart_sn011-2 Heart_sn011
- GSM6321370 Heart_sn011-3 Heart_sn011
- GSE236006 The effect of STING antagonist SN-011 on the gene expression changes in the mouse brain after ischemic stroke 12 samples shares sn-011, changes
- GSE226594 The effect of the STING antagonist on the gene expression changes in the kidney of Trex1 -/- mice 9 samples shares trex1, changes
- GSE336537 Transcriptome changes driving multiple regulatory pathways involved in TGF-β-induced Anterior Subcapsular Cataract 10 samples shares multiple, changes
- GSE300591 Temporal changes in metabolism guide oligodendrocyte precursor cell dynamics in aging and multiple sclerosis 15 samples shares multiple, changes
- GSE290383 Induced loss of TREX1 in host cells inflames the tumor micromilieu and invigorates CTL-mediated cancer control 12 samples shares trex1
- GSE271340 Single-cell sequencing of CD45-positive and CD45 negative cells from the lungs of WT, Trex1 KO, Trex1;Ifngr1 DKO, and cGas-KI/+;Vav-icre mice 4 samples shares trex1
- GSE205991 Multiple subpopulations in medullary thymic epithelial cells are regulated by Aire with distinctive modes of gene regulations [deep single-cell RNA-seq] 2148 samples shares multiple
- GSE299704 Meta-analysis of the brain transcriptomes of multiple genetic mouse models of schizophrenia highlights dysregulation in striatum and thalamus 235 samples shares multiple
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.