GEO series
Transcriptome changes in multiple tissues of Trex1 knockout mouse after SN-011 administration
GSE207859
Mus musculus
Expression profiling by high throughput sequencing
24 samples
2026/05/15
GPL17021
Summary
Trex1 is known as a major cellular 3'-to-5' exonuclease which could digest both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Loss of Trex1 led to cell-intrinsic initiation of autoimmunity. Here, we investigated transcriptome changes in multiple tissues of Trex1 knockout mouse after SN-011 administration
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Paper (PMID 41773721) ↗
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