GEO series
Transcriptome of human peripheral blood regulatory T cells with distinct ex vivo expansion profile
GSE208111
Homo sapiens
Expression profiling by high throughput sequencing
19 samples
2024/04/17
GPL24676
Summary
The UCSF Treg cell therapy program manufactured over 60 human regulatory T cell (Treg) products under the GMP condition in support of 9 clinical trials between 2011 and 2021. These products were manufactured using two alternative protocols of either two rounds of polyclonal stimulations (PolyTregs) or first allogeneic B cell stimulation followed by polyclonal stimulation (arTregs). A high degree of individual variability in Treg expansion with both protocols was observed. RNA-seq analysis was performed on freshly isolated peripheral blood Tregs to identify transcriptome profile associated with Treg expansions.
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Paper (PMID 36322627) ↗
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