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Exosomes targeting Myc reverse the proneural-mesenchymal transition and extend the survival of end-stage glioblastoma mice [DroNc-seq ]

GSE208323 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2024/04/11 Platform GPL18573
Summary
Exosomes generated from human bone marrow Mesenchymal Stem cells (MSC) and engineered to encapsulate different anti-Myc siRNAs (iExo-Myc) and scramble-siRNAs (iExo-Scr) were administered via retro-orbital injection to mice harboring late stage intracranial U87 tumor xenografts. Tumor growth and survival were monitored, and tumor xenografts were collected and transcriptionally profiled.
Published in
Engineered exosomes targeting MYC reverse the proneural-mesenchymal transition and extend survival of glioblastoma
Haltom AR, Hassen WE, Hensel J et al. · Extracellular vesicle 2022 · PMID 37503329 · doi:10.1016/j.vesic.2022.100014
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Also filed as BioProject PRJNA859186 and SRA study SRP386684. Searching any of these in the dataset finder brings you back here.

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