Activin A and CCR2 regulate the function of macrophages in testicular fibrosis caused by experimental autoimmune orchitis
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × BMDM, untreated, day 6 vs 3 × BMDM, 50 ng/ml activin A, day 6 vs 3 × BMDM, 50 ng/ml activin A, 250 ng/ml FST, day 6 vs 3 × BMDM, 250 ng/ml FST, day 6Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Activin A and CCR2 regulate macrophage function in testicular fibrosis caused by experimental autoimmune orchitisCellular and molecular life sciences : CMLS · 2022
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE210004_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA863301 and SRA study SRP388631. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6413325 BMDM, untreated, day 6 1 BMDM, untreated, day 6
- GSM6413326 BMDM, untreated, day 6 2 BMDM, untreated, day 6
- GSM6413327 BMDM, untreated, day 6 3 BMDM, untreated, day 6
- GSM6413328 BMDM, 50 ng/ml activin A, day 6 1 BMDM, 50 ng/ml activin …
- GSM6413329 BMDM, 50 ng/ml activin A, day 6 2 BMDM, 50 ng/ml activin …
- GSM6413330 BMDM, 50 ng/ml activin A, day 6 3 BMDM, 50 ng/ml activin …
- GSM6413331 BMDM, 50 ng/ml activin A, 250 ng/ml FST, day 6 1 BMDM, 50 ng/ml activin …
- GSM6413332 BMDM, 50 ng/ml activin A, 250 ng/ml FST, day 6 2 BMDM, 50 ng/ml activin …
- GSM6413333 BMDM, 50 ng/ml activin A, 250 ng/ml FST, day 6 3 BMDM, 50 ng/ml activin …
- GSM6413334 BMDM, 250 ng/ml FST, day 6 1 BMDM, 250 ng/ml FST, da…
- GSM6413335 BMDM, 250 ng/ml FST, day 6 2 BMDM, 250 ng/ml FST, da…
- GSM6413336 BMDM, 250 ng/ml FST, day 6 3 BMDM, 250 ng/ml FST, da…
- GSE284505 Chronic sleep deprivation promotes experimental autoimmune uveitis through STAT1 phosphorylation, ISG15 expression and enhanced pathogenicity of macrophages 12 samples shares experimental, macrophages, autoimmune
- GSE287323 Transcriptomic profiling of oligodendrocytes, astrocytes, and microglia in an experimental autoimmune encephalomyelitis (EAE) model of demyelination 19 samples shares experimental, autoimmune
- GSE282695 STAT3 regulates pathogen control and clearance in macrophages by reprogramming inflammation-induced microbial defense response 18 samples shares macrophages, regulate
- GSE243269 The RNA binding protein HNRNPA2B1 regulates IFNG signaling in macrophages 12 samples shares macrophages, regulate
- GSE325061 Ubiquitylation by the GID/CTLH complex regulates the metabolic and innate immune response of macrophages to infection by Mycobacterium tuberculosis 12 samples shares macrophages, regulate
- GSE231992 Diet-induced obesity dysregulates rapid epigenetic response to hypoxia in macrophages (RNA-Seq) 12 samples shares macrophages, regulate
- GSE277303 Inducible CCR2+ nonclassical monocytes mediate the regression of cancer metastasis 42 samples shares ccr2
- GSE272755 Transcriptional effects of lysosome stress on mouse bone marrow-derived macrophages and primary microglia 263 samples shares macrophages
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.