Transcriptomic profiling of oligodendrocytes, astrocytes, and microglia in an experimental autoimmune encephalomyelitis (EAE) model of demyelination
RNA-seq (gene expression) · mouse · 19 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 19 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Injury-transduced SerpinOLs modulate neuroinflammation and glial activation in the diseased and non-diseased CNSbioRxiv : the preprint server for biology · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE287323_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1212135 and SRA study SRP558166. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 19 samples.
How we read this: 6 replicated groups read from 19 sample titles; they account for 19 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8743905 CFA_Ctrl_OL_1 CFA_Ctrl_OL
- GSM8743906 CFA_Ctrl_OL_2 CFA_Ctrl_OL
- GSM8743907 CFA_Ctrl_OL_3 CFA_Ctrl_OL
- GSM8743908 MOG_Ctrl_OL_1 MOG_Ctrl_OL
- GSM8743909 MOG_Ctrl_OL_2 MOG_Ctrl_OL
- GSM8743910 MOG_Ctrl_OL_3 MOG_Ctrl_OL
- GSM8743911 CFA_Ctrl_Astro_1 CFA_Ctrl_Astro
- GSM8743912 CFA_Ctrl_Astro_2 CFA_Ctrl_Astro
- GSM8743913 CFA_Ctrl_Astro_3 CFA_Ctrl_Astro
- GSM8743914 MOG_Ctrl_Astro_1 MOG_Ctrl_Astro
- GSM8743915 MOG_Ctrl_Astro_2 MOG_Ctrl_Astro
- GSM8743916 MOG_Ctrl_Astro_3 MOG_Ctrl_Astro
- GSM8743917 MOG_Ctrl_Astro_4 MOG_Ctrl_Astro
- GSM8743918 CFA_Ctrl_MG_1 CFA_Ctrl_MG
- GSM8743919 CFA_Ctrl_MG_2 CFA_Ctrl_MG
- GSM8743920 CFA_Ctrl_MG_3 CFA_Ctrl_MG
- GSM8743921 MOG_Ctrl_MG_1 MOG_Ctrl_MG
- GSM8743922 MOG_Ctrl_MG_2 MOG_Ctrl_MG
- GSM8743923 MOG_Ctrl_MG_3 MOG_Ctrl_MG
- GSE243235 Analysis of a non-obese diabetes-experimental autoimmune encephalomyelitis (NOD-EAE) 15 samples shares eae, encephalomyelitis, experimental, autoimmune
- GSE234291 MAIT cells in experimental autoimmune encephalomyelitis (EAE) 12 samples shares eae, encephalomyelitis, experimental, autoimmune
- GSE287324 Transcriptomic analysis of spinal cord in day 35 experimental autoimmune encephalomyelitis (EAE) model 10 samples shares eae, encephalomyelitis, experimental, autoimmune
- GSE253318 Transcriptional profiling and multiple machine learning methods identified novel microglia biomarkers for Experimental Autoimmune Encephalomyelitis 16 samples shares encephalomyelitis, experimental, autoimmune, microglia
- GSE287320 Transcriptomic profiling of oligodendrocytes, astrocytes, and microglia in a cuprizone-induced demyelination model 14 samples shares oligodendrocytes, demyelination, astrocytes, microglia
- GSE262540 Myelin oligodendrocyte glycoprotein reactive Th17 cells drive Janus Kinase 1 dependent transcriptional reprogramming in astrocytes and alter cell surface cytokine receptor profiles during experimental autoimmune encephalomyelitis. 12 samples shares encephalomyelitis, experimental, astrocytes, autoimmune
- GSE298934 Activation of M3 muscarinic ameliorates experimental autoimmune encephalomyelitis by restoring microglial quiescence 9 samples shares encephalomyelitis, experimental, autoimmune, microglia
- GSE275400 Brd4 expression in microglia supports microglial activation, T cell recruitment, and demyelination in EAE 16 samples shares eae, demyelination, microglia
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.