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Soluble VE-cadherin disrupts endothelial barrier function via VE-PTP/RhoA signalling

GSE210502 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/10/01 Platform GPL18573
Summary
We generated recombinant human sVE-cadherin (extracellular domains EC1-5) which was applied to human dermal microvascular endothelial cells (HDMEC) to investigate it`s role in endothelial barrier function. In other experiments we observed that sVE-cadherin disrupted endothelial barrier function by dismantling the VE-cadherin complex at cell borders via VE-PTP-dependent RhoA activation. The sequencing project compares untreated HDMEC vs treated cells.
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Direct links to NCBI, no account and no request form: the whole study as GSE210502_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA865806 and SRA study SRP389792. Searching any of these in the dataset finder brings you back here.

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