GEO series
Ancestralization of the modern human aryl hydrocarbon receptor by genome editing
GSE210514
Homo sapiens
Expression profiling by high throughput sequencing
60 samples
2024/06/26
GPL16791
Summary
The aryl hydrocarbon receptor (AHR) is a transcription factor that upon binding ligands induces the expression of cytochrome P450 genes, which encode enzymes that metabolize aromatic hydrocarbons. The AHR carries an amino acid substitution at position 381 in all present-day humans that occurred after the divergence of modern humans from Neandertals and Denisovans. Here, we use genome editing to revert position 381 back to the ancestral state in human cells. Cells were treated with ligands for 4 h followed by RNA extraction and RNA-Seq.
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Paper (PMID 38739836) ↗
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