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Host responses to S. pneumoniae in wild type and Mertk mutant mice XT

GSE210551 Mus musculus (mouse) RNA-seq (gene expression) 91 samples Submitted 2025/03/03 Platform GPL24247Platform GPL21103
At a glance

RNA-seq (gene expression) · mouse · 91 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Mus musculus (mouse)
Samples
91 samples: 12 conditions, mostly with about 11 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Host responses to S. pneumoniae in wild type and Mertk mutant micePloS one · 2025
SuperSeries — this record groups several sub-series.
Summary (written by the submitters)
This SuperSeries is composed of the SubSeries listed below.
Published in
Host responses to S. pneumoniae in wild type and Mertk mutant mice
McPeek MK, Martin JR, Gomez JC et al. · PloS one 2025 · PMID 40238852 · doi:10.1371/journal.pone.0320660
This dataset
Open GSE210551 in finder → Find more mouse RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE210551_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA866143 and SRA study SRP389973. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 40238852) ↗
Study design
12 conditions, mostly with about 11 replicates each
Alveolar macrophage_Mertk-/-_Female ×11 Alveolar macrophage_Mertk-/-_Male ×11 Alveolar macrophage_Wild type_Female ×11 Alveolar macrophage_Wild type_Male ×11 Left lung_Pneumonic_Mertk-/-_Male ×8 Left lung_Pneumonic_Wild type_Male ×8 In vitro_Alveolar macrophage_Mertk-/-_4h Unst… ×6 In vitro_Alveolar macrophage_Wild type_4h Uns… ×6 +4 more

Supports a between-group comparison across 91 samples.

How we read this: 12 replicated groups read from 91 sample titles; they account for 91 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

+ 51 more — browse all 91 samples with per-sample file links →

Datasets on a similar topic

Search all mouse RNA-seq datasets in GEO →

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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.