AAV9-medated cardiac expression of lncRNA CARDINAL ameliorate TAC induced hypertrophy
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 4 × 39_Sham vs 4 × 39_TAC vs 4 × Ctrl_Sham vs 4 × Ctrl_TACGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- The long noncoding RNA CARDINAL attenuates cardiac hypertrophy by modulating protein translationThe Journal of clinical investigation · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE210983_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA868412 and SRA study SRP390951. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 4 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6443659 39_Sham_1 39_Sham
- GSM6443660 39_Sham_2 39_Sham
- GSM6443661 39_Sham_3 39_Sham
- GSM6443662 39_Sham_4 39_Sham
- GSM6443663 39_TAC_1 39_TAC
- GSM6443664 39_TAC_4 39_TAC
- GSM6443665 39_TAC_5 39_TAC
- GSM6443666 39_TAC_6 39_TAC
- GSM6443667 Ctrl_Sham_1 Ctrl_Sham
- GSM6443668 Ctrl_Sham_2 Ctrl_Sham
- GSM6443669 Ctrl_Sham_3 Ctrl_Sham
- GSM6443670 Ctrl_Sham_4 Ctrl_Sham
- GSM6443671 Ctrl_TAC_1 Ctrl_TAC
- GSM6443672 Ctrl_TAC_3 Ctrl_TAC
- GSM6443673 Ctrl_TAC_4 Ctrl_TAC
- GSM6443674 Ctrl_TAC_7 Ctrl_TAC
- GSE261561 Contribution of VEGF-B-induced endocardial endothelial cell lineage in physiological versus pathological cardiac hypertrophy. 12 samples shares hypertrophy, cardiac, induced
- GSE305453 Perturb-seq uncovers pathological obstacles to direct cardiac reprogramming in vivo 15 samples shares tac, cardiac
- GSE267447 Loss of Nuclear Receptor Nr4a3 Alleviates Cellular Senescence to Promote Adult Direct Cardiac Reprogramming (ATAC-Seq) 16 samples shares tac, cardiac
- GSE325579 NEMO lysine mutant mice reveal ROS-RelA signaling required for optimal CD40-induced humoral immunity [NEMODK_ATACSeq] 12 samples shares tac, induced
- GSE322779 Transcription factor TFEB antagonizes cardiac hypertrophy and failure by enhancing lysosomal capacity and mitochondrial function 16 samples shares hypertrophy, cardiac
- GSE307584 Aberrant Upregulation of Histamine N-Methyltransferase Exacerbates Pathological Cardiac Hypertrophy and Heart Failure via Disruption of SAM/Frizzled-2/ CaMKII Signaling Pathway [RNA-seq] 12 samples shares hypertrophy, cardiac
- GSE329337 ATAD3A Limits Aortic Dissection via Mito-Lysosome Contacts and Lipoylation 24 samples shares tac
- GSE208359 Itaconate mediates an immunometabolic crosstalk between osteoclasts and osteoblasts 24 samples shares tac
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.