Contribution of VEGF-B-induced endocardial endothelial cell lineage in physiological versus pathological cardiac hypertrophy.
Single-cell RNA-seq · mouse · 12 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Contribution of VEGF-B-Induced Endocardial Endothelial Cell Lineage in Physiological Versus Pathological Cardiac HypertrophyCirculation research · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE261561_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1087443 and SRA study SRP495125. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8146665 WT_SVF_scRNA-seq
- GSM8146666 αMHC_SVF_scRNA-seq
- GSM8146667 aP2_SVF_scRNA-seq
- GSM8146668 WT_ECs_scRNA-seq
- GSM8146669 αMHC_ECs_scRNA-seq
- GSM8146670 aP2_ECs_scRNA-seq
- GSM8146671 WT_2_days_post_LAD_ECs_scRNA-seq
- GSM8146672 αMHC_2_days_post_LAD_ECs_scRNA-seq
- GSM8146673 WT_18_days_pregnant_ECs_scRNA-seq
- GSM8146674 αMHC_18_days_pregnant_ECs_scRNA-seq
- GSM8146675 WT_7_days_post_delivery_ECs_scRNA-seq
- GSM8146676 αMHC_7_days_post_delivery_ECs_scRNA-seq
- GSE310548 Distinct contributions of Etv2+ and Flk1+ progenitors to endothelial, hematopoietic, and cardiac lineages [RNA-seq] 21 samples shares contribution, endothelial, lineage
- GSE307584 Aberrant Upregulation of Histamine N-Methyltransferase Exacerbates Pathological Cardiac Hypertrophy and Heart Failure via Disruption of SAM/Frizzled-2/ CaMKII Signaling Pathway [RNA-seq] 12 samples shares pathological, hypertrophy
- GSE246928 Endothelial RNF20 Suppresses Endothelial-to-Mesenchymal Transition and Safeguards Physiological Angiocrine Signaling to Prevent Congenital Heart Disease 12 samples shares physiological, endothelial
- GSE315915 Exercise Metabolic Memory Halts Pathological Cardiac Hypertrophy via PDK4 10 samples shares pathological, hypertrophy
- GSE304791 SPOP is a key trigger of pathological cardiac hypertrophy and heart failure 10 samples shares pathological, hypertrophy
- GSE243527 RNA‑seq profiling of mRNA associated with aged related Pathological cardiac hypertrophy 6 samples shares pathological, hypertrophy
- GSE314005 TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure through PKN2 Ubiquitination 6 samples shares pathological, hypertrophy
- GSE307365 Endothelial IL-36 receptor activation promotes vascular stability to limit pathological microvessel permeability in the CNS 6 samples shares pathological, endothelial
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.