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Transcription profiles of MED23-KD and wildtype 293T cells

GSE211083 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/05/28 Platform GPL24676
Summary
To characterize the function of MED23 on transcription, we generated two MED23-KD 293T cell lines in which MED23 was about 75% knockouted by CRISPR-Cas9. Then we performed RNA-seq to analyze the change of transcript levels around termination sites.
Published in
Mediator regulates transcriptional termination through crosstalk with pre-mRNA 3' end processing factors
Lu C, Bai X, Zhang H et al. · Molecular cell 2025 · PMID 40441154 · doi:10.1016/j.molcel.2025.05.006
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Also filed as BioProject PRJNA868784 and SRA study SRP391156. Searching any of these in the dataset finder brings you back here.

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