GEO series

OCT4 Knockdown in human embryonic stem cells

GSE21135 Homo sapiens Expression profiling by array 12 samples Submitted 2010/04/05 Platform GPL6947

Summary

We studied the genomic locations of three key regulatory proteins (OCT4, NANOG and CTCF) in human and mouse embryonic stem (ES) cells [see Series GSE20650]. To identify the conserved and unique human OCT4 targets, we performed an OCT4 RNAi knock-down experiment. We find that species-specific transposable elements have profoundly altered the transcriptional circuitry of pluripotent stem cells.

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Direct links to NCBI, no account and no request form: the whole study as GSE21135_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 12 samples.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗

Also filed as BioProject PRJNA129669. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 20526341) ↗

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