Targeting STAT3-FoxO1 axis reverses de novo and acquired PARP inhibitor resistance independent of BRCA status
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 31 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 31 samples: 26 distinct titles, 5 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE212435_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA875420 and SRA study SRP395077. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 31 sample titles: 26 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6532745 RNA_Seq_FoxO1_SUM159_Con_DMSO_REP1
- GSM6532746 RNA_Seq_FoxO1_SUM159_Con_DMSO_REP2
- GSM6532747 RNA_Seq_FoxO1_SUM159_shFoxO1_DMSO_REP1
- GSM6532748 RNA_Seq_FoxO1_SUM159_shFoxO1_DMSO_REP2
- GSM6532749 RNA_Seq_FoxO1_SUM159_Con_Olap_REP1
- GSM6532750 RNA_Seq_FoxO1_SUM159_Con_Olap_REP2
- GSM6532751 RNA_Seq_FoxO1_SUM159_shFoxO1_Olap_REP1
- GSM6532752 RNA_Seq_FoxO1_SUM159_shFoxO1_Olap_REP2
- GSM6532765 ChIP_seq_Vector_Olap
- GSM6532766 ChIP_seq_FoxO1_HA_DMSO
- GSM6532767 ChIP_seq_FoxO1_HA_Olap
- GSM6532781 WES_Case1_pre
- GSM6532782 WES_Case1_post
- GSM6532783 WES_Case2_pre
- GSM6532784 WES_Case2_post
- GSM6532785 WES_Case3_pre
- GSM6532786 WES_Case3_post
- GSM6532787 WES_Case4_pre
- GSM6532788 WES_Case4_post
- GSM6595273 WES_OC316_SENS
- GSM6595274 WES_OC316_RES
- GSM6595275 WES_HCC1937_SENS
- GSM6595276 WES_HCC1937_RES
- GSM6595277 WES_PDX_USTC11
- GSM6595278 WES_PDX_LTL-313HR
- GSM6595279 WES_PDX_A5002
- GSM6595280 WES_PDX_A9007
- GSM6595281 WGS_Case5_pre
- GSM6595282 WGS_Case5_post
- GSM6892370 ChIP_seq_pSTAT3_DMSO
- GSM6892371 ChIP_seq_pSTAT3_Olap
- GSE243143 Codon Specific Readthrough as a Mechanism of BRCA2 Restoration in Acquired PARP Inhibitor and Chemotherapy Resistance 13 samples shares parp, brca, resistance, inhibitor
- GSE243141 Codon Specific Readthrough as a Mechanism of BRCA2 Restoration in Acquired PARP Inhibitor and Chemotherapy Resistance [RNA-seq] 10 samples shares parp, brca, resistance, inhibitor
- GSE314447 Low physiological pH drives P300-mediated acetylation of PARP1 and promotes PARP inhibitor resistance [RNA-seq] 18 samples shares parp, resistance, inhibitor
- GSE281556 Lysosomal sequestration of PARP inhibitors drives heterogeneous accumulation in ovarian cancer to increase efficacy 204 samples shares parp, inhibitor
- GSE222557 Neoadjuvant PARPi or Chemotherapy in Ovarian Cancer Informs Targeting Effector Treg Cells for Homologous-Recombination-Deficient Tumors 148 samples shares parp, targeting
- GSE281517 Lysosomal sequestration of PARP inhibitors drives heterogeneous accumulation in ovarian cancer to increase efficacy [RNA-seq] 72 samples shares parp, inhibitor
- GSE222556 Neoadjuvant PARPi or Chemotherapy in Ovarian Cancer Informs Targeting Effector Treg Cells for Homologous-Recombination-Deficient Tumors [10x scRNA-seq] 67 samples shares parp, targeting
- GSE322780 PARP1 Suppression Drives ROS Resistance in Aneuploid Cancer Cells 46 samples shares parp, resistance
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.