The protective effects of exercise training on heart failure with preserved ejection fraction
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 4 × C vs 4 × E vs 4 × HGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE212839_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA877663 and SRA study SRP396100. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 3 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6556490 C1 C
- GSM6556491 C2 C
- GSM6556492 C3 C
- GSM6556493 C4 C
- GSM6556494 E1 E
- GSM6556495 E2 E
- GSM6556496 E3 E
- GSM6556497 E4 E
- GSM6556498 H1 H
- GSM6556499 H2 H
- GSM6556500 H3 H
- GSM6556501 H4 H
- GSE269053 Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension 21 samples shares preserved, ejection, fraction, failure, heart
- GSE240401 Upregulated FoxO1 promotes arrhythmogenesis in mice with heart failure and preserved ejection fraction [control vs HF] 14 samples shares preserved, ejection, fraction, failure, heart
- GSE218761 Cardiac reprogramming and Gata4 overexpression reduce fibrosis and improve diastolic dysfunction in heart failure with preserved ejection fraction 18 samples shares preserved, ejection, fraction, failure, heart
- GSE253735 Loss of skeletal muscle Bmal1 +/- Exercise Training [Mouse liver, heart, inguinal white adipose and lung tissues 64 samples shares exercise, training, heart
- GSE307900 Comparative analysis of isoproterenol and lipopolysaccharide mediated cytoprotective responses in the heart 23 samples shares protective, heart
- GSE324100 Exercise Training Prior To and During Cancer in Mice Preserves Muscle Mass, Reduces Tumor Weight, and Suppresses Molecular Mediators of Cachexia 22 samples shares exercise, training
- GSE302911 Endurance training promotes chromatin closure and timely repression of the post-exercise immediate early stress response [RNA-Seq] 21 samples shares exercise, training
- GSE302867 Cardiac adaptation to endurance exercise training requires suppression of GDF15 via PGC-1α 20 samples shares exercise, training
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.