Cardiac reprogramming and Gata4 overexpression reduce fibrosis and improve diastolic dysfunction in heart failure with preserved ejection fraction
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 18 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 18 samples: 18 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Cardiac Reprogramming and Gata4 Overexpression Reduce Fibrosis and Improve Diastolic Dysfunction in Heart Failure With Preserved Ejection FractionCirculation · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE218761_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA905408 and SRA study SRP409763. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 18 sample titles: 18 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6755871 Ctrl, normal chow, replicate1, RNA-seq
- GSM6755872 Ctrl, normal chow, replicate2, RNA-seq
- GSM6755873 Ctrl, normal chow, replicate3, RNA-seq
- GSM6755874 Ctrl, Heart failure, replicate1, RNA-seq
- GSM6755875 Ctrl, Heart failure, replicate2, RNA-seq
- GSM6755876 Ctrl, Heart failure, replicate3, RNA-seq
- GSM6755877 TTg, Heart failure, replicate1, RNA-seq
- GSM6755878 TTg, Heart failure, replicate2, RNA-seq
- GSM6755879 TTg, Heart failure, replicate3, RNA-seq
- GSM6756153 Ctrl, normal chow, replicate1, scRNA-seq
- GSM6756154 Ctrl, normal chow, replicate2, scRNA-seq
- GSM6756155 Ctrl, Heart failure, replicate1, scRNA-seq
- GSM6756156 Ctrl, Heart failure, replicate2, scRNA-seq
- GSM6756157 TTg, Heart failure, replicate1, scRNA-seq
- GSM6756158 TTg, Heart failure, replicate2, scRNA-seq
- GSM6756178 Ctrl, normal chow, Visium
- GSM6756179 TTg, Heart failure, Visium
- GSM6756180 Ctrl, Heart failure, Visium
- GSE280553 NNMT overexpression promotes tubular senescence and fibrosis in human chronic kidney disease (young, old and NAM-supplemented old mice kidney) [Series_4] 22 samples shares overexpression, fibrosis
- GSE241176 Fibroblast-specific TGF-b signaling mediates dysfunction, fibrosis and hypertrophy in a mouse model of obesity-associated type 2 diabetes [RNA-seq: Smad3 in dbdb] 12 samples shares dysfunction, fibrosis
- GSE204933 Age-associated chromatin reorganization drives overexpression of a novel Btaf1 variant regulating HSC self-renewal and MkP differentiation in male mice 82 samples shares overexpression
- GSE278100 Foxa1-Mediated Chromatin Remodeling and Enhancer Reprogramming Promotes Gemcitabine Resistance in Pancreatic Cancer 54 samples shares reprogramming
- GSE294772 Single-Cell Epigenomics Uncovers Heterochromatin Instability and Transcription Factor Dysfunction during Mouse Brain Aging [snATAC-Seq] [10X Multiome] 142 samples shares dysfunction
- GSE237954 Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer 122 samples shares reprogramming
- GSE313769 SATB1 Lowers The TCR Signaling Threshold For Thymocytes Positive Selection via Super-enhancer Reprogramming 122 samples shares reprogramming
- GSE319035 P21+TREM2+-Senescent Macrophages Fuel Inflammaging and Metabolic Dysfunction-Associated Steatotic Liver Disease [NAFLD_time_course] 77 samples shares dysfunction
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.