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Stimulation with THBS4 activates pathways that regulate proliferation, migration and inflammation in primary human keratinocytes

GSE213737 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/12/28 Platform GPL18573
Summary
Atopic dermatitis, which is a common inflammatory skin disease characterized by persistent epidermal barrier dysfunction, is a systemic health burden reducing overall quality of life of the person. Recently, we showed that the nonstructural extracellular matrix molecule Thrombospondin-4 (THBS4) was upregulated in psoriatic skin lesions by more than 2-fold. In addition, THBS4 contributed to both skin regeneration and wound healing in vitro and in vivo. In the present work we found that THBS4 is also abundantly expressed in AD patient skin biopsies. By using a proteotransciptomic approach we show that stimulation of primary keratinocytes with THBS4 activates multiple factors, including inflammation, migration, proliferation, keratinocyte differentiation, by which THBS4 could participate in AD progression and contribute to the wound healing process.
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Stimulation with THBS4 activates pathways that regulate proliferation, migration and inflammation in primary human keratinocytes
Mäemets-Allas K, Klaas M, Cárdenas-León CG et al. · Biochemical and biophysical research communications 2023 · PMID 36566568 · doi:10.1016/j.bbrc.2022.12.052
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Also filed as BioProject PRJNA882338 and SRA study SRP398182. Searching any of these in the dataset finder brings you back here.

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