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RNA-seq of RPE cells that harbor a C-terminal GFP-tag on the splicing factor PRPF8 and the retinitis pigmentosa mutation Y2334N

GSE213805 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2025/03/12 Platform GPL18573
Summary
RPE cells were edited using CRISPR/Cas9 to fuse a GFP-tag at the C-terminus of PRPF8 and additionally mutate amino acid 2334 from Y to N.
Published in
Retinitis pigmentosa-linked mutations impair the snRNA unwinding activity of SNRNP200 and reduce pre-mRNA binding of PRPF8
Zimmann F, McNicoll F, Thakur PK et al. · Cellular and molecular life sciences : CMLS 2025 · PMID 40045025 · doi:10.1007/s00018-025-05621-z
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Also filed as BioProject PRJNA882471 and SRA study SRP398280. Searching any of these in the dataset finder brings you back here.

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