GEO series
Transcriptome-wide mapping of RNA:protein interactions of PRPF8 and SNRNP200 (BRR2) with retinitis pigmentosa (RP) mutations by iCLIP
GSE213806
Homo sapiens
Expression profiling by high throughput sequencing; Other
27 samples
2025/03/12
GPL11154
Summary
We used HeLa cells that express GFP-tagged PRPF8 with and without the RP mutations F2314L and Y2334N at physiological levels as well as SNRNP200-GFP with and without the RP mutations S1087L and R1090L and performed iCLIP using anti-GFP antibodies. We also used RPE cells with and without the Y2334N mutation inserted by CRISPR/Cas9 and compared their binding pattern on snRNAs and pre-mRNAs.
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Paper (PMID 40045025) ↗
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