Hepatocyte CCAAT/enhancer-binding protein alpha restricts liver fibrosis by inhibiting secreted phosphoprotein 1 expression
RNA-seq (gene expression) · mouse · 42 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 42 samples: 10 conditions, mostly with about 5 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Hepatocyte-specific CCAAT/enhancer binding protein α restricts liver fibrosis progressionThe Journal of clinical investigation · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE214616_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA886402 and SRA study SRP395433. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 42 samples.
How we read this: 10 replicated groups read from 42 sample titles; they account for 42 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6542293 HFD8WT10D_KO1 HFD8WT10D_KO
- GSM6542294 HFD8WT10D_WT1 HFD8WT10D_WT
- GSM6542295 HFD8WT10D_KO2 HFD8WT10D_KO
- GSM6542296 HFD8WT10D_KO3 HFD8WT10D_KO
- GSM6542297 HFD8WT10D_WT2 HFD8WT10D_WT
- GSM6542298 HFD8WT10D_WT3 HFD8WT10D_WT
- GSM6542299 HFD8WT10D_WT4 HFD8WT10D_WT
- GSM6542300 HFD8WT10D_KO4 HFD8WT10D_KO
- GSM6542301 HFD8WT10D_KO5 HFD8WT10D_KO
- GSM6542302 HFD8WT10D_WT5 HFD8WT10D_WT
- GSM6542303 HFD12WT10W_KO1 HFD12WT10W_KO
- GSM6542304 HFD12WT10W_KO2 HFD12WT10W_KO
- GSM6542305 HFD12WT10W_KO3 HFD12WT10W_KO
- GSM6542306 HFD12WT10W_WT1 HFD12WT10W_WT
- GSM6542307 HFD12WT10W_WT2 HFD12WT10W_WT
- GSM6542308 HFD12WT10W_KO4 HFD12WT10W_KO
- GSM6542309 HFD12WT10W_WT3 HFD12WT10W_WT
- GSM6542310 HFD12WT10W_WT4 HFD12WT10W_WT
- GSM6542311 HFD12WT10W_WT5 HFD12WT10W_WT
- GSM6542312 HFD12WT10W_KO5 HFD12WT10W_KO
- GSM6542313 AlbCBHFD2W_WT1 AlbCBHFD2W_WT
- GSM6542314 AlbCBHFD2W_WT2 AlbCBHFD2W_WT
- GSM6542315 AlbCBHFD2W_WT3 AlbCBHFD2W_WT
- GSM6542316 AlbCBHFD2W_WT4 AlbCBHFD2W_WT
- GSM6542317 AlbCBHFD2W_WT5 AlbCBHFD2W_WT
- GSM6542318 AlbCBHFD2W_KO2 AlbCBHFD2W_KO
- GSM6542319 AlbCBHFD2W_KO3 AlbCBHFD2W_KO
- GSM6542320 AlbCBHFD2W_KO4 AlbCBHFD2W_KO
- GSM6542321 AlbCBHFD2W_KO5 AlbCBHFD2W_KO
- GSM6542322 AlbCBHFD2W_KO6 AlbCBHFD2W_KO
- GSM6613102 PMH, WT1 PMH, WT
- GSM6613103 PMH, WT2 PMH, WT
- GSM6613104 PMH, WT3 PMH, WT
- GSM6613105 PMH, KO1 PMH, KO
- GSM6613106 PMH, KO2 PMH, KO
- GSM6613107 PMH, KO3 PMH, KO
- GSM6613108 PMH, GFP1 PMH, GFP
- GSM6613109 PMH, GFP2 PMH, GFP
- GSM6613110 PMH, GFP3 PMH, GFP
- GSM6613111 PMH, OE1 PMH, OE
+ 2 more — browse all 42 samples with per-sample file links →
- GSE212646 Hepatocyte CCAAT/enhancer-binding protein alpha restricts liver fibrosis by inhibiting secreted phosphoprotein 1 expression (I) 30 samples shares ccaat, enhancer-binding, phosphoprotein, hepatocyte, inhibiting, restricts, fibrosis, secreted
- GSE214615 Hepatocyte CCAAT/enhancer-binding protein alpha restricts liver fibrosis by inhibiting secreted phosphoprotein 1 expression (II) 12 samples shares ccaat, enhancer-binding, phosphoprotein, hepatocyte, inhibiting, restricts, fibrosis, secreted
- GSE279171 CCAAT/enhancer-binding proteins alpha and beta directly regulate ovulation and selectively regulate gene expression in granulosa cells by preovulatory stage- and dose-dependent mechanisms 18 samples shares ccaat, enhancer-binding
- GSE233051 A cyclic peptide-grafted Fc with hepatocyte growth factor functionality ameliorates hepatic fibrosis in a non-alcoholic steatohepatitis mouse model. 36 samples shares hepatocyte, fibrosis
- GSE309637 Effects of TCDD on gene expression in hepatocytes isolated from WT and PkmΔDRE mice. 144 samples shares hepatocyte
- GSE246914 Genomic and Transcriptomic Analyses of Chemical Hepatocarcinogenesis Aggravated by Loss of Oncoproteins in Hepatocytes [RNA-Seq] 105 samples shares hepatocyte
- GSE266938 Deletion of SWI/SNF ATPase activity in hepatocytes of adult liver disrupts circadian gene expression and central liver functions [RNAseq] 82 samples shares hepatocyte
- GSE248554 Hepatocytes differentiate into intestinal epithelial cells through a hybrid epithelial/mesenchymal cell state in culture II 49 samples shares hepatocyte
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.