GEO series
Enhancer engagement sustains oncogenic transformation and progression of B-cell precursor acute lymphoblastic leukemia
GSE214916
Homo sapiens
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other
57 samples
2024/06/27
GPL24676GPL18573
Summary
Numerous evidence report that non-genetic-driven events such as enhancer reprogramming promotes neoplastic transformation and strongly contribute to the phenotypical heterogeneity of cancers as much as genetic variation. In this study, we investigated the role of enhancers in sustaining oncogenic transformation in Paediatric B-cell Acute Lymphoblastic Leukemia (ALL-B), a type of cancer caused by the accumulation of lymphoid progenitor cells in the bone marrow.
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Paper (PMID 38926853) ↗
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