The significance of PAX5 in Merkel cell carcinoma
DNA methylation · human · 39 samples
- What it is
- DNA methylationChemical marks on DNA that help switch genes on or off.
- Organism
- Homo sapiens (human)
- Topic
- Merkel cell carcinomaThis series is part of our curated briefing on it.
- Samples
- 39 samples: 15 × L-MCC vs 14 × Merkel_cell carcinoma_tissue_L-MCC vs 2 × Merkel_cell carcinoma_cell_line_MKLGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed expression table (series matrix) and the array files, from NCBI.
- Paper
- The significance of PAX5 in Merkel cell carcinomaThe Journal of pathology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE214948_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for beta-value tables or raw IDAT files among the supplementary files.
Also filed as BioProject PRJNA887776 and SRA study SRP401339. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 31 samples.
How we read this: 3 replicated groups read from 39 sample titles; they account for 31 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6619046 Merkel_cell carcinoma_tissue_L-MCC2 Merkel_cell carcinoma_t…
- GSM6619047 Merkel_cell carcinoma_tissue_L-MCC4 Merkel_cell carcinoma_t…
- GSM6619048 Merkel_cell carcinoma_tissue_L-MCC5 Merkel_cell carcinoma_t…
- GSM6619049 Merkel_cell carcinoma_tissue_L-MCC7 Merkel_cell carcinoma_t…
- GSM6619050 Merkel_cell carcinoma_tissue_L-MCC10 Merkel_cell carcinoma_t…
- GSM6619051 Merkel_cell carcinoma_tissue_L-MCC8 Merkel_cell carcinoma_t…
- GSM6619052 Merkel_cell carcinoma_tissue_L-MCC16 Merkel_cell carcinoma_t…
- GSM6619053 Merkel_cell carcinoma_tissue_L-MCC11 Merkel_cell carcinoma_t…
- GSM6619054 Merkel_cell carcinoma_tissue_L-MCC12 Merkel_cell carcinoma_t…
- GSM6619055 Merkel_cell carcinoma_tissue_L-MCC13 Merkel_cell carcinoma_t…
- GSM6619056 Merkel_cell carcinoma_tissue_L-MCC14 Merkel_cell carcinoma_t…
- GSM6619057 Merkel_cell carcinoma_tissue_L-MCC15 Merkel_cell carcinoma_t…
- GSM6619058 Merkel_cell carcinoma_tissue_L-MCC17 Merkel_cell carcinoma_t…
- GSM6619059 Merkel_cell carcinoma_tissue_L-MCC18 Merkel_cell carcinoma_t…
- GSM6619060 Merkel_cell carcinoma_cell_line_MKL-1 Merkel_cell carcinoma_c…
- GSM6619061 Merkel_cell carcinoma_cell_line_MKL-2 Merkel_cell carcinoma_c…
- GSM6619062 Merkel_cell carcinoma_cell_line_WaGa
- GSM6619063 Merkel_cell carcinoma_cell_line_MCC13
- GSM6619064 pre_B-cell_acute-lymphoblastic_cell_line_REH
- GSM6619071 MKL-1 cells
- GSM6619072 MKL-2 cells
- GSM6619073 WaGa cells
- GSM6619074 MCC13 cells
- GSM6619075 REH cells
- GSM6619076 L-MCC2 L-MCC
- GSM6619077 L-MCC4 L-MCC
- GSM6619078 L-MCC5 L-MCC
- GSM6619079 L-MCC6 L-MCC
- GSM6619080 L-MCC7 L-MCC
- GSM6619081 L-MCC10 L-MCC
- GSM6619082 L-MCC8 L-MCC
- GSM6619083 L-MCC16 L-MCC
- GSM6619084 L-MCC11 L-MCC
- GSM6619085 L-MCC12 L-MCC
- GSM6619086 L-MCC13 L-MCC
- GSM6619087 L-MCC14 L-MCC
- GSM6619088 L-MCC15 L-MCC
- GSM6619089 L-MCC17 L-MCC
- GSM6619090 L-MCC18 L-MCC
- GSE235093 Pre-existing skin-resident CD8 and γδ T cell circuits mediate immune response in Merkel cell carcinoma and Predict immunotherapy efficacy 333 samples same disease briefing · shares merkel
- GSE39612 Distinct gene expression profiles of viral- and non-viral associated Merkel cell carcinoma revealed by transcriptome analysis 138 samples same disease briefing · shares merkel
- GSE292992 MDM2 degradation overcomes feedback regulation of p53 signaling in Merkel cell carcinoma 66 samples same disease briefing · shares merkel
- GSE317774 ATR inhibition induces NF-κB-dependent immunogenicity in Merkel cell carcinoma independent of cGAS-STING 48 samples same disease briefing · shares merkel
- GSE261681 Interlocking core regulatory circuits enable viral hijacking in Merkel cell carcinoma 43 samples same disease briefing · shares merkel
- GSE154938 Glucose-6-Phosphate Dehydrogenase as a Prognostic Predictor Correlates with the Tumor Immune Activity Including Programmed Death Ligand-1 Expression in Merkel Cell Carcinoma 41 samples same disease briefing · shares merkel
- GSE22396 Gene expression analysis of Merkel Cell Carcinoma 35 samples same disease briefing · shares merkel
- GSE326661 Reprogramming engineered autologous T cells to overcome resistance in Merkel cell carcinoma [scRNA-seq] 22 samples same disease briefing · shares merkel
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.