Opposing transcription factors MYCL and HEY1 mediate the Notch-dependent airway stem cell fate decision
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 15 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 15 samples: 15 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE215066_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA888348 and SRA study SRP401547. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 15 sample titles: 15 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6620450 Foxj1-CreERT Rosa-tdTomato mTECs at air/liquid interface for 3 days, TdTomato sorted, replicate 1
- GSM6620451 Foxj1-CreERT Rosa-tdTomato mTECs at air/liquid interface for 3 days, unsorted, replicate 1
- GSM6620452 wild-type mTEC at air/liquid interface for 3 days, replicate 1
- GSM6620453 wild-type mTECs at air/liquid interface for 3 days, replicate 2
- GSM6620658 MYCL-GFP, GFP antibody, replicate 1, CUT&RUN
- GSM6620659 MYCL-GFP, GFP antibody, replicate 2, CUT&RUN
- GSM6620660 nlsGFP, control for MYCL 1, GFP antibody, replicate 1, CUT&RUN
- GSM6620661 nlsGFP, control for MYCL 2, GFP antibody, replicate 2, CUT&RUN
- GSM6620662 HEY1-GFP, replicate 1, CUT&RUN
- GSM6620663 HEY1-GFP, replicate 2, CUT&RUN
- GSM6620664 nlsGFP, control for HEY1 1, replicate 1 , CUT&RUN
- GSM6620665 nlsGFP, control for HEY1 2, replicate 2, CUT&RUN
- GSM6620669 Control nontargeting guide, mTECs at air/liquid interface for 5 days, replicate 1
- GSM6620670 Guide targeting Gmnc, mTECs at air/liquid interface for 5 days, replicate 1
- GSM6620671 Guide targeting Mcidas, mTECs at air/liquid interface for 5 days, replicate 1
- GSE283382 N6-methyladenosine modulate second cell fate decision by enhancing mRNA stability of pivotal transcription factors during primitive endoderm development [TBLC_RNAseq] 98 samples shares transcription, decision, factors
- GSE243165 Signal-responsive transcription factors cooperate to establish alveolar macrophage identity 42 samples shares transcription, factors
- GSE286046 Asymmetric Histone Inheritance Regulates Differential Transcription Re-initiation and Cell Fate Decisions in Mouse Olfactory Horizontal Basal Cells 96 samples shares transcription, decision
- GSE282280 DNA methylation-sensitive transcription factors and bivalency orchestrate transposon expression in the absence of DNA methylation. 93 samples shares transcription, factors
- GSE281037 Large-scale transcriptomic analyses reveal downstream target genes of ZFY1 and ZFY2 transcription factors in male germ cells 48 samples shares transcription, factors
- GSE283958 Cohesin recruitment to promoters and enhancers by general transcription factors and chromatin regulators 47 samples shares transcription, factors
- GSE326173 Nuclear receptor Nur77 resolves the inflammatory response of macrophages primarily by regulating expression of AP-1 transcription factors and their target genes [ChIP-seq] 42 samples shares transcription, factors
- GSE242179 Role of the histone variant H2A.Z.1 in memory, transcription, and alternative splicing is mediated by lysine modification 40 samples shares transcription, mediate
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.