Mutant IDH1 cooperates with NPM1c or FLT3-ITD to drive distinct myeloid diseases and molecular outcomes
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 153 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 153 samples: 36 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Mutant IDH1 cooperates with NPM1c or FLT3(ITD) to drive distinct myeloid diseases and molecular outcomesProceedings of the National Academy of Sciences of the United States of America · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE215370_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA889922 and SRA study SRP402285. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 153 samples.
How we read this: 36 replicated groups read from 153 sample titles; they account for 153 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6634415 3mo WT Rep1 3mo WT
- GSM6634416 3mo WT Rep2 3mo WT
- GSM6634417 3mo WT Rep3 3mo WT
- GSM6634418 3mo WT Rep4 3mo WT
- GSM6634419 3mo IDH1 Rep1 3mo IDH1
- GSM6634420 3mo IDH1 Rep2 3mo IDH1
- GSM6634421 3mo IDH1 Rep3 3mo IDH1
- GSM6634422 3mo IDH1 Rep4 3mo IDH1
- GSM6634423 3mo NPM1 Rep2 3mo NPM1
- GSM6634424 3mo NPM1 Rep3 3mo NPM1
- GSM6634425 3mo NPM1 Rep4 3mo NPM1
- GSM6634426 3mo IDH1NPM1 Rep1 3mo IDH1NPM1
- GSM6634427 3mo IDH1NPM1 Rep2 3mo IDH1NPM1
- GSM6634428 3mo IDH1NPM1 Rep3 3mo IDH1NPM1
- GSM6634429 3mo IDH1NPM1 Rep4 3mo IDH1NPM1
- GSM6634430 3mo FLT3 Rep1 3mo FLT3
- GSM6634431 3mo FLT3 Rep2 3mo FLT3
- GSM6634432 3mo FLT3 Rep3 3mo FLT3
- GSM6634433 3mo FLT3 Rep4 3mo FLT3
- GSM6634434 3mo IDH1FLT3 Rep1 3mo IDH1FLT3
- GSM6634435 3mo IDH1FLT3 Rep2 3mo IDH1FLT3
- GSM6634436 3mo IDH1FLT3 Rep3 3mo IDH1FLT3
- GSM6634437 3mo IDH1FLT3 Rep4 3mo IDH1FLT3
- GSM6634438 6mo WT Rep1 6mo WT
- GSM6634439 6mo WT Rep2 6mo WT
- GSM6634440 6mo WT Rep3 6mo WT
- GSM6634441 6mo WT Rep4 6mo WT
- GSM6634442 6mo IDH1 Rep1 6mo IDH1
- GSM6634443 6mo IDH1 Rep2 6mo IDH1
- GSM6634444 6mo IDH1 Rep3 6mo IDH1
- GSM6634445 6mo IDH1 Rep4 6mo IDH1
- GSM6634446 6mo NPM1 Rep1 6mo NPM1
- GSM6634447 6mo NPM1 Rep2 6mo NPM1
- GSM6634448 6mo NPM1 Rep3 6mo NPM1
- GSM6634449 6mo NPM1 Rep4 6mo NPM1
- GSM6634450 6mo IDH1NPM1 Rep1 6mo IDH1NPM1
- GSM6634451 6mo IDH1NPM1 Rep2 6mo IDH1NPM1
- GSM6634452 6mo IDH1NPM1 Rep3 6mo IDH1NPM1
- GSM6634453 6mo IDH1NPM1 Rep4 6mo IDH1NPM1
- GSM6634454 6mo FLT3 Rep1 6mo FLT3
+ 113 more — browse all 153 samples with per-sample file links →
- GSE318348 Single cell LARRY state-fate analysis of Npm1cA/Flt3-ITD acute myeloid leukemia stem cells 20 samples shares flt3-itd, npm1c, myeloid
- GSE329858 Mutant IDH1 blocks neutropoiesis by repressing myeloid progenitor programs [ATAC-seq] 6 samples shares idh1, myeloid, mutant
- GSE329878 Mutant IDH1 blocks neutropoiesis by repressing myeloid progenitor programs [bulk RNA-Seq] 6 samples shares idh1, myeloid, mutant
- GSE330314 Mutant IDH1 blocks neutropoiesis by repressing myeloid progenitor programs [scRNA-seq] 4 samples shares idh1, myeloid, mutant
- GSE215369 Gene expression profiles of cKit positive bone marrow cells from six genotype mice - WT, Idh1R132, Npm1c, Flt3ITD, Idh1R132+Npm1c, and Idh1R132+Flt3ITD 54 samples shares npm1c, idh1
- GSE215368 DNA methylation profiles of cKit positive bone marrow cells from six genotype mice - WT, Idh1R132, Npm1c, Flt3ITD, Idh1R132+Npm1c, and Idh1R132+Flt3ITD 52 samples shares npm1c, idh1
- GSE215367 Chromation accessibility profiles of cKit positive bone marrow cells from six genotype mice - WT, Idh1R132, Npm1c, Flt3ITD, Idh1R132+Npm1c, and Idh1R132+Flt3ITD 47 samples shares npm1c, idh1
- GSE266686 Mutant IDH1 inhibition induces dsDNA sensing to activate tumor immunity [ChIP-Seq] 32 samples shares idh1, mutant
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.