GEO series
Single cell LARRY state-fate analysis of Npm1cA/Flt3-ITD acute myeloid leukemia stem cells
GSE318348
Mus musculus
Expression profiling by high throughput sequencing; Other
20 samples
2026/03/01
GPL30172
Summary
AML leukemia stem cells are principal drivers of leukemia disease. Leveraging novel leukemia stem cell cultures (PLSTCs) we performed state-fate analysis to understand the trajectories of distinct AML LSC clones in vivo and ex vivo using a LARRY expressed barcoding strategy. The results indicate that self-renewing LSCs show clonally-heritable programs that predict in vivo engraftment, fitness and therapy response. Targeting those programs using a CROPseq perturbation and single-cell sequencing approach, we identify a novel mechanism regulating the LSC state.
Download
NCBI GEO page ↗
{# Names what the click gives you. "Open in finder" meant nothing to a
visitor who arrived from a search engine and has never seen the tool. #}
Find more
mouse RNA-seq datasets →
Similar datasets
- GSE334689 m6Am-seq profiling of macrophage-specific Pcif1 knockout mice during experimental colitis 8 samples
- GSE269045 Inflammatory immune modulators of AML lung infiltration and respiratory failure 56 samples
- GSE337460 Chlamydia serovars in uterus- scRNA-seq, CITE-seq and TCRab 30 samples
- GSE327213 Increased mRNA translation delays tumor initiation and exposes a therapeutic vulnerability in lung cancer 16 samples
- GSE327939 High-Resolution Lineage Tracing in Native Tissue Contexts 79 samples
- GSE314859 The degradation of maternal RNA-binding protein 4E-T regulates translational activation to ensure maternal-to-zygotic transition in mouse embryos 67 samples
- GSE249405 Spatial mapping of RNA turnover kinetics in the mouse brain 38 samples
- GSE285147 Astrocyte molecular changes during basolateral amygdala-related emotional behaviors [set2] 23 samples
Share this dataset
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.