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Comparison of the gene expression profile in aorta tissue between C57BL/6J and Apoe-knockout mouse

GSE215969 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2024/10/31 Platform GPL21273
Summary
The physiological functions other than lipid metabolism of APOE may interfere with the research results of Apoe-knockout mice as atherosclerosis models. The elucidation of the molecular basis of the physiological functions of APOE other than lipid metabolism will help to make rational use of the Apoe-knockout mouse model. Therefore, our aim is to reveal the changes in aortic gene expression profile caused by Apoe-knockout. We used the second generation sequencing to detect the gene mRNA expression level in the aortic tissues of 5 C57BL/6J mice and 4 Apoe knockout mice. This will provide more clues for studying the physiological function of Apoe, and also remind researchers to pay special attention to the possible interference to the results when using Apoe-knockout mice as atherosclerosis models.
Published in
Apoe-knockout induces strong vascular oxidative stress and significant changes in the gene expression profile related to the pathways implicated in redox, inflammation, and endothelial function
Liu B, Fang L, Mo P et al. · Cellular signalling 2023 · PMID 37409402 · doi:10.1016/j.cellsig.2023.110696
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Also filed as BioProject PRJNA891358 and SRA study SRP403107. Searching any of these in the dataset finder brings you back here.

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