Engineered T cell therapy for central nervous system injury
RNA-seq (gene expression) · mouse · 230 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 230 samples: 25 conditions, mostly with about 12 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Engineered T cell therapy for central nervous system injuryNature · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE216391_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA893390 and SRA study SRP348442. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 216 samples.
How we read this: 25 replicated groups read from 230 sample titles; they account for 216 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM5708094 Diaphragm
- GSM5708095 Blood
- GSM5708096 Meninges_1 Meninges
- GSM5708097 Meninges_2 Meninges
- GSM6671693 Spinal Cord A1 Spinal Cord A
- GSM6671694 Spinal Cord A2 Spinal Cord A
- GSM6671695 Spinal Cord A3 Spinal Cord A
- GSM6671696 Spinal Cord A4 Spinal Cord A
- GSM6671697 Spinal Cord A5 Spinal Cord A
- GSM6671698 Spinal Cord A6 Spinal Cord A
- GSM6671699 Spinal Cord A7 Spinal Cord A
- GSM6671700 Spinal Cord A8 Spinal Cord A
- GSM6671701 Spinal Cord A9 Spinal Cord A
- GSM6671702 Spinal Cord A10 Spinal Cord A
- GSM6671703 Spinal Cord A11 Spinal Cord A
- GSM6671704 Spinal Cord A12 Spinal Cord A
- GSM6671705 Spinal Cord B1 Spinal Cord B
- GSM6671706 Spinal Cord B2 Spinal Cord B
- GSM6671707 Spinal Cord B3 Spinal Cord B
- GSM6671708 Spinal Cord B4 Spinal Cord B
- GSM6671709 Spinal Cord B5 Spinal Cord B
- GSM6671710 Spinal Cord B6 Spinal Cord B
- GSM6671711 Spinal Cord B7 Spinal Cord B
- GSM6671712 Spinal Cord B8 Spinal Cord B
- GSM6671713 Spinal Cord B9 Spinal Cord B
- GSM6671714 Spinal Cord B10 Spinal Cord B
- GSM6671715 Spinal Cord B11 Spinal Cord B
- GSM6671716 Spinal Cord B12 Spinal Cord B
- GSM6671717 Spinal Cord C1 Spinal Cord C
- GSM6671718 Spinal Cord C2 Spinal Cord C
- GSM6671719 Spinal Cord C3 Spinal Cord C
- GSM6671720 Spinal Cord C4 Spinal Cord C
- GSM6671721 Spinal Cord C5 Spinal Cord C
- GSM6671722 Spinal Cord C6 Spinal Cord C
- GSM6671723 Spinal Cord C7 Spinal Cord C
- GSM6671724 Spinal Cord C8 Spinal Cord C
- GSM6671725 Spinal Cord C9 Spinal Cord C
- GSM6671726 Spinal Cord C10 Spinal Cord C
- GSM6671727 Spinal Cord C11 Spinal Cord C
- GSM6671728 Spinal Cord C12 Spinal Cord C
+ 190 more — browse all 230 samples with per-sample file links →
- GSE285529 CD133+PD-L1+ cancer cells confer resistance to adoptively transferred engineered macrophage-based therapy in melanoma. 30 samples shares engineered, therapy
- GSE303870 A tumor-associated macrophage-targeted immunocytokine leveraging T and NK cell synergy for potent cancer immunotherapy 223 samples shares therapy
- GSE174554 A single cell atlas of human glioma under therapy 113 samples shares therapy
- GSE314854 Targeting Modulated Vascular Smooth Muscle Cells in Atherosclerosis via FAP-Directed Immunotherapy 102 samples shares therapy
- GSE285990 Chemotherapy triggers immune evasion by fostering LEPR+ Kupffer cell differentiation in liver metastases [RNA-seq] 23 samples shares therapy
- GSE255517 Rational design of immune gene therapy combinations via in vivo CRISPR activation screening of tumor microenvironment modulators 57 samples shares therapy
- GSE293919 Longitudinal monitoring of cytoplasmic RBP-RNA interactions and transcriptome in living cells by engineered protein nanocages 424 samples shares engineered
- GSE304029 BRD2 Bromodomain-Mediated Regulation of Cell State Plasticity Modulates Therapy Response in Glioblastoma 56 samples shares therapy
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.