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Transcriptomic heterogeneity of endothelial cells during devleopmental angiogenesis

GSE216594 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2024/04/29 Platform GPL19057
Summary
Efficient angiogenesis, the formation of new blood vessels from pre-existing vessels, underlie tissue growth during development. Blood vessels in the mouse ear has been shown to dramatically expand at the neonatal stage to meet the needs of postnatal tissue growth. Yet, it is not clear at the transcriptome level how endothelial cells lining the innermost layer of blood vessels drive angiogenesis at this developmental stage. The highly heterogeneous endothelial cell types during angiogenesis render traditional bulk RNA-sequencing unsuitable. Therefore, we utilized single-cell RNA- and CITE-seq to profile transcriptomic heterogeneity of both blood and lymphatic endothelial cells during developmental angiogenesis in mouse ear.
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Direct links to NCBI, no account and no request form: the whole study as GSE216594_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA894482 and SRA study SRP404625. Searching any of these in the dataset finder brings you back here.

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