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scRNA-seq analysis revealed the molecular characteristics of erythroid cells in spleen upon HAPC

GSE216683 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/10/01 Platform GPL24247
Summary
High-altitude polycythemia (HAPC) is a most common chronic mountain sickness, characterized by excessive erythrocytosis caused primarily by persistent arterial hypoxia and ventilatory impairment. It has been a serious public health problem in high-altitude regions. Despite numerous studies on HAPC via genomics, transcriptomics or metabolome approaches, the pathogenesis of HAPC remains largely unclear. Here, we performed single-cell RNA sequencing to reveal the change of transcriptomics profiles of MNC in spleen of mice between HAPC subjects and healthy controls.
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Direct links to NCBI, no account and no request form: the whole study as GSE216683_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA894967 and SRA study SRP404865. Searching any of these in the dataset finder brings you back here.

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