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PRDM16 regulates the postnatal fate of embryonic radial glia via VCAM1-dependent mechanisms

GSE218159 Mus musculus Expression profiling by high throughput sequencing 7 samples Submitted 2024/12/30 Platform GPL24247
Summary
Postnatally, a subpopulation of embryonic neural stem cells becomes adult neural stem cells, which primarily generate olfactory bulb interneurons in mice. Although embryonic and adult neural stem cells have been characterized, the mechanisms that regulate the transition from embryonic to adult neural stem cells remain poorly understood. We show that PR domain-containing 16 (Prdm16) promotes the transition from embryonic to adult neural stem cells. By single-cell RNA sequencing, it reveals postnatal persistence of radial glia in Prdm16 cKO mice.
Published in
Prdm16 regulates the postnatal fate of embryonic radial glia via Vcam1-dependent mechanisms
Li J, Godoy MI, Lu Y et al. · Nature communications 2025 · PMID 40683857 · doi:10.1038/s41467-025-60895-y
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Also filed as BioProject PRJNA902489 and SRA study SRP408330. Searching any of these in the dataset finder brings you back here.

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