SRSF1 knockdown alleviates the ribosomal stress-induced inhibition of cell proliferation through the MAPK signaling pathway
RNA-seq (gene expression) · human · 15 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 15 samples: 5 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE218461_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA903897 and SRA study SRP409000. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 15 samples.
How we read this: 5 replicated groups read from 15 sample titles; they account for 15 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6745580 con_1 con
- GSM6745581 con_2 con
- GSM6745582 con_3 con
- GSM6745583 sta_1 sta
- GSM6745584 sta_2 sta
- GSM6745585 sta_3 sta
- GSM6745586 srsf1_1 srsf1
- GSM6745587 srsf1_2 srsf1
- GSM6745588 srsf1_3 srsf1
- GSM6745589 srpk1_1 srpk1
- GSM6745590 srpk1_2 srpk1
- GSM6745591 srpk1_3 srpk1
- GSM6745592 upf1_1 upf1
- GSM6745593 upf1_2 upf1
- GSM6745594 upf1_3 upf1
- GSE303051 Prolonged KRAS-MAPK Inhibition Induces Interferon-mediated Epithelial-to-Mesenchymal Transition and Reveals Therapeutic Opportunities. 30 samples shares mapk, inhibition
- GSE270062 Autophagy inhibition induced by EM-2 augments apoptosis via ROS-mediated ATM-Chk2-p53-p21 and MAPK pathway in lung and breast carcinoma 4 samples shares mapk, inhibition
- GSE248208 Cooperation between the Hippo and MAPK pathway activation drives acquired resistance to TEAD inhibition 99 samples shares mapk, inhibition
- GSE280280 Reprogramming of Cellular Plasticity via ETS and MYC Core-regulatory circuits During Response to MAPK Inhibition in BRAF-mutant colorectal cancer 36 samples shares mapk, inhibition
- GSE303106 Prolonged KRAS-MAPK Inhibition Induces Interferon-mediated Epithelial-to-Mesenchymal Transition and Reveals Therapeutic Opportunities [cut and run-ChipSeq] 9 samples shares mapk, inhibition
- GSE270406 Pharmacological or genetic inhibition of LTCC promotes cardiomyocyte proliferation through inhibition of calcineurin activity 10 samples shares proliferation, inhibition
- GSE233121 Metabolism-dependent secondary effect of anti-MAPK cancer therapy on DNA repair [QuantSeq_Q_siCTU2] 72 samples shares mapk
- GSE233122 Metabolism-dependent secondary effect of anti-MAPK cancer therapy on DNA repair [RNAseq_siRNA_MAPKi] 36 samples shares mapk
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.