GEO series
Urotensin II Activates Sensory-cutaneous Pathway to Promote Itch and Cutaneous Inflammation
GSE218749
Mus musculus; Homo sapiens
Expression profiling by high throughput sequencing
12 samples
2025/11/23
GPL28457GPL28038
Summary
In order to study the effect of UII on the transcription level regulation of itch-related genes in sensory neurons and keratinocytes, and to apply UII in mouse dorsal root ganglion neuronal cells and keratinocytes, the study showed that UII significantly upregulated the expression of various characteristics of atopic dermatitis and itch-related genes, such as Fasl, Mrgprx1, Amy2a3, INHBA, IL36G, STEAP2, etc.
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