GEO series
Functional inhibition of core spliceosomal machinery activates intronic premature cleavage and polyadenylation of pre-mRNAs
GSE250342
Mus musculus; Homo sapiens
Expression profiling by high throughput sequencing
36 samples
2025/01/29
GPL20795GPL24676GPL21273
Summary
To investigate the extent to which U6 inhibits premature cleavage and polyadenylation at the transcriptome level. we performed 3’-seq in control, U1 and U6-AMO treated sample using lexogen 3’-seq kit (Cat. 016.24) that could accurately quantify the global PAS usage. Indeed, we found both U1 and U6 could globally suppress intronic PCPA.
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Paper (PMID 40019833) ↗
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