GEO series
Single cell transcriptome profiling of kidney cell populations and the effect of liraglutide in diabetes
GSE220045
Mus musculus
Expression profiling by high throughput sequencing
17 samples
2024/05/02
GPL13112
Summary
While incretin-based therapies are known to improve glucose control in diabetes, growing evidence suggests a glucose-independent mechanism in protection against kidney disease. To further investigate incretin effects in kidney, we examined long-term therapy with liraglutide, a Glucagon-like peptide 1 receptor (GLP1R) agonist, in diabetic (Ins2Akita) and control mice and profiled renal cell transcriptomes using single-cell sequencing.
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Paper (PMID 38069998) ↗
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