Splicing Factor RBM22 Broadly Affects RNA Polymerase II 5' Pausing, Elongation Rate and Termination and Prevents Genome Instability
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 70 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 70 samples: 18 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- RBM22 regulates RNA polymerase II 5' pausing, elongation rate, and termination by coordinating 7SK-P-TEFb complex and SPT5Genome biology · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE220318_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA909625 and SRA study SRP411832. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 38 samples.
How we read this: 18 replicated groups read from 70 sample titles; they account for 38 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6798226 POLR2G_ChIP_22KD_rep1 POLR2G_ChIP_22KD
- GSM6798227 POLR2G_ChIP_22KD_rep2 POLR2G_ChIP_22KD
- GSM6798228 POLR2G_ChIP_NC_rep1 POLR2G_ChIP_NC
- GSM6798229 POLR2G_ChIP_NC_rep2 POLR2G_ChIP_NC
- GSM6798230 POLR2G_Input_22KD_rep1 POLR2G_Input_22KD
- GSM6798231 POLR2G_Input_22KD_rep2 POLR2G_Input_22KD
- GSM6798232 POLR2G_Input_NC_rep1 POLR2G_Input_NC
- GSM6798233 POLR2G_Input_NC_rep2 POLR2G_Input_NC
- GSM6798234 SPT5_ChIP_22KD_rep1 SPT5_ChIP_22KD
- GSM6798235 SPT5_ChIP_22KD_rep2 SPT5_ChIP_22KD
- GSM6798236 SPT5_ChIP_NC_rep1 SPT5_ChIP_NC
- GSM6798237 SPT5_ChIP_NC_rep2 SPT5_ChIP_NC
- GSM6798238 SPT5_Input_22KD_rep1 SPT5_Input_22KD
- GSM6798239 SPT5_Input_22KD_rep2 SPT5_Input_22KD
- GSM6798240 SPT5_Input_NC_rep1 SPT5_Input_NC
- GSM6798241 SPT5_Input_NC_rep2 SPT5_Input_NC
- GSM6798242 CDK9_ChIP_22KD_rep1 CDK9_ChIP_22KD
- GSM6798243 CDK9_ChIP_22KD_rep2 CDK9_ChIP_22KD
- GSM6798244 CDK9_ChIP_NC_rep1 CDK9_ChIP_NC
- GSM6798245 CDK9_ChIP_NC_rep2 CDK9_ChIP_NC
- GSM6798246 CDK9_Input_22KD_rep1 CDK9_Input_22KD
- GSM6798247 CDK9_Input_22KD_rep2 CDK9_Input_22KD
- GSM6798248 CDK9_Input_NC_rep1 CDK9_Input_NC
- GSM6798249 CDK9_Input_NC_rep2 CDK9_Input_NC
- GSM6798250 HEXIM1_ChIP_22KD_rep1 HEXIM1_ChIP_22KD
- GSM6798251 HEXIM1_ChIP_22KD_rep2 HEXIM1_ChIP_22KD
- GSM6798252 HEXIM1_ChIP_NC_rep1 HEXIM1_ChIP_NC
- GSM6798253 HEXIM1_ChIP_NC_rep2 HEXIM1_ChIP_NC
- GSM6798254 HEXIM1_Input_22KD_rep1 HEXIM1_Input_22KD
- GSM6798255 HEXIM1_Input_22KD_rep2 HEXIM1_Input_22KD
- GSM6798256 HEXIM1_Input_NC_rep1 HEXIM1_Input_NC
- GSM6798257 HEXIM1_Input_NC_rep2 HEXIM1_Input_NC
- GSM6798258 POLR2A_ChIP_22KD1_0min
- GSM6798259 POLR2A_ChIP_22KD1_10min
- GSM6798260 POLR2A_ChIP_22KD1_20min
- GSM6798261 POLR2A_ChIP_22KD1_5min
- GSM6798262 POLR2A_ChIP_22KD2_0min
- GSM6798263 POLR2A_ChIP_22KD2_10min
- GSM6798264 POLR2A_ChIP_22KD2_20min
- GSM6798265 POLR2A_ChIP_22KD2_5min
+ 30 more — browse all 70 samples with per-sample file links →
- GSE220316 Splicing Factor RBM22 Broadly Affects RNA Polymerase II 5' Pausing, Elongation Rate and Termination and Prevents Genome Instability [ChIP-seq] 64 samples shares rbm22, termination, instability, polymerase, elongation, splicing, prevents, broadly
- GSE228346 The TFIIH kinase CDK7 governs RNA polymerase II initiation, elongation, termination, and RNA processing 30 samples shares termination, polymerase, elongation
- GSE235181 Promoter-proximal RNA polymerase II termination regulates transcription during human cell type transition 44 samples shares termination, polymerase
- GSE280208 A CDK11-dependent RNA polymerase II pause-release checkpoint precedes CDK9-mediated transition to transcriptional elongation [ChIP-Seq] 33 samples shares polymerase, elongation
- GSE292907 Selective CDK7 Inhibition Sensitizes Tumors to Topoisomerase I Inhibitor-Antibody Drug Conjugates by Blocking The Transition of The RNA polymerase II Initiation Complex into Elongation [ChIP-seq] 97 samples shares polymerase, elongation
- GSE265881 Tripartite phosphorylation of SPT5 by CDK9 times pause release and tunes elongation rate of RNA polymerase II (ChIP-Seq) 72 samples shares polymerase, elongation
- GSE265883 Tripartite phosphorylation of SPT5 by CDK9 times pause release and tunes elongation rate of RNA polymerase II (CUT&RUN) 68 samples shares polymerase, elongation
- GSE223052 TFIIIC and MYCN link the three-dimensional chromatin structure of promoters to transcription termination of stalled RNA polymerase (ChIPseq CnR) 32 samples shares termination, polymerase
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.