METTL3 Promotes Histone H3K9 Acetylation through Recruitment of Histone Acetyltransferase 1 to Chromatin
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 43 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 43 samples: 19 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE220870_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA911762 and SRA study SRP412840. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 38 samples.
How we read this: 19 replicated groups read from 43 sample titles; they account for 38 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6824849 293T, Input, rep1 293T, Input,
- GSM6824850 293T, Input, rep2 293T, Input,
- GSM6824851 METTL3-KO, Input, rep1 METTL3-KO, Input,
- GSM6824852 METTL3-KO, Input, rep2 METTL3-KO, Input,
- GSM6824853 293T, m6A-IP, rep1 293T, m6A-IP,
- GSM6824854 293T, m6A-IP, rep2 293T, m6A-IP,
- GSM6824855 METTL3-KO, m6A-IP, rep1 METTL3-KO, m6A-IP,
- GSM6824856 METTL3-KO, m6A-IP, rep2 METTL3-KO, m6A-IP,
- GSM6824876 HEK293T, Input
- GSM6824877 METTL3 knockout, Input
- GSM6824878 HEK293T, H3K9Ac-ChIP, rep1 HEK293T, H3K9Ac-ChIP,
- GSM6824879 HEK293T, H3K9Ac-ChIP, rep2 HEK293T, H3K9Ac-ChIP,
- GSM6824880 METTL3 knockout, H3K9Ac-ChIP, rep1 METTL3 knockout, H3K9Ac…
- GSM6824881 METTL3 knockout, H3K9Ac-ChIP, rep2 METTL3 knockout, H3K9Ac…
- GSM6824882 METTL3 knockout with wildtype METTL3 rescue, H3K9Ac-ChIP, rep1 METTL3 knockout with wi…
- GSM6824883 METTL3 knockout with wildtype METTL3 rescue, H3K9Ac-ChIP, rep2 METTL3 knockout with wi…
- GSM6824884 METTL3 knockout with mutated METTL3 rescue, H3K9Ac-ChIP, rep1 METTL3 knockout with mu…
- GSM6824885 METTL3 knockout with mutated METTL3 rescue, H3K9Ac-ChIP, rep2 METTL3 knockout with mu…
- GSM7802807 HEK293T, Input (Input-WT)
- GSM7802808 FTO knockout, Input
- GSM7802809 ALKBH5 knockout, Input
- GSM7802810 HEK293T, H3K9ac-ChIP, rep1 HEK293T, H3K9ac-ChIP,
- GSM7802811 HEK293T, H3K9ac-ChIP, rep2 HEK293T, H3K9ac-ChIP,
- GSM7802812 FTO knockout, H3K9ac-ChIP, rep1 FTO knockout, H3K9ac-Ch…
- GSM7802813 FTO knockout, H3K9ac-ChIP, rep2 FTO knockout, H3K9ac-Ch…
- GSM7802814 ALKBH5 knockout, H3K9ac-ChIP, rep1 ALKBH5 knockout, H3K9ac…
- GSM7802815 ALKBH5 knockout, H3K9ac-ChIP, rep2 ALKBH5 knockout, H3K9ac…
- GSM7802816 293T, 10min, RNA-seq rep1 293T, 10min, RNA-seq
- GSM7802817 293T, 10min, RNA-seq rep2 293T, 10min, RNA-seq
- GSM7802818 293T, 20min, RNA-seq rep1 293T, 20min, RNA-seq
- GSM7802819 293T, 20min, RNA-seq rep2 293T, 20min, RNA-seq
- GSM7802820 293T, 30min, RNA-seq rep1 293T, 30min, RNA-seq
- GSM7802821 293T, 30min, RNA-seq rep2 293T, 30min, RNA-seq
- GSM7802822 293T, 60min, RNA-seq rep1 293T, 60min, RNA-seq
- GSM7802823 293T, 60min, RNA-seq rep2 293T, 60min, RNA-seq
- GSM7802824 METTL3 knockout, 10min, RNA-seq rep1 METTL3 knockout, 10min,…
- GSM7802825 METTL3 knockout, 10min, RNA-seq rep2 METTL3 knockout, 10min,…
- GSM7802826 METTL3 knockout, 20min, RNA-seq rep1 METTL3 knockout, 20min,…
- GSM7802827 METTL3 knockout, 20min, RNA-seq rep2 METTL3 knockout, 20min,…
- GSM7802828 METTL3 knockout, 30min, RNA-seq rep1 METTL3 knockout, 30min,…
+ 3 more — browse all 43 samples with per-sample file links →
- GSE243987 METTL3 Promotes Histone H3K9 Acetylation through Recruitment of Histone Acetyltransferase 1 to Chromatin [Nascent RNA-seq] 16 samples shares mettl3, h3k9, acetyltransferase, acetylation, recruitment, chromatin, promotes, histone
- GSE256135 DNA hypomethylation promotes UHRF1- and SUV39H1/H2-dependent crosstalk between H3K18ub and H3K9me3 to reinforce heterochromatin states 77 samples shares h3k9, chromatin, promotes
- GSE288140 HDAC2-Mediated Recruitment of METTL3 to Chromatin Regulates Human Embryonic Stem Cell Differentiation 74 samples shares mettl3, recruitment, chromatin
- GSE256116 DNA hypomethylation promotes UHRF1- and SUV39H1/H2-dependent crosstalk between H3K18ub and H3K9me3 to reinforce heterochromatin states 36 samples shares h3k9, chromatin, promotes
- GSE255352 Hypoxia promotes histone H3K9 lactylation to enhance LAMC2 transcription in esophageal squamous cell carcinoma 16 samples shares h3k9, promotes, histone
- GSE282925 DNA hypomethylation promotes UHRF1- and SUV39H1/H2-dependent crosstalk between H3K18ub and H3K9me3 to reinforce heterochromatin states [RNA-Seq] 12 samples shares h3k9, chromatin, promotes
- GSE256114 DNA hypomethylation promotes UHRF1- and SUV39H1/H2-dependent crosstalk between H3K18ub and H3K9me3 to reinforce heterochromatin states 12 samples shares h3k9, chromatin, promotes
- GSE285328 Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin [RNA-seq] 6 samples shares mettl3, acetylation, chromatin
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.