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Spatial Multi-omics Reveals the Heterogeneity of Tumor Microenvironment in the OSF-Associated OSCC

GSE220978 Homo sapiens Expression profiling by high throughput sequencing; Other 4 samples Submitted 2024/03/05 Platform GPL24676
Summary
Oral submucous fibrosis (OSF) is one of the most common precancerous malignant orders (PMO) with high rates exacerbating into oral squamous cell carcinoma (OSCC), mostly occurred in patients with chewing betel-nut habits in Southeast Asia and Pacific region. However, the spatial characteristics and heteogeneities of tumor microenvironment (TME) in OSF-associated OSCC still remains unclear. Here, we characterized the spatiotemporal changes of OSF-associated OSCC at different malignant states by performing 10x Visium Spatial Transcriptomics (ST) sequencing and airflow-assisted desorption electrospray ionization-mass spectrometry imaging (AFADESI-MSI) analysis.
Published in
Spatial Transcriptomic and Metabolomic Landscapes of Oral Submucous Fibrosis-Derived Oral Squamous Cell Carcinoma and its Tumor Microenvironment
Zhi Y, Wang Q, Zi M et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 · PMID 38229179 · doi:10.1002/advs.202306515
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Also filed as BioProject PRJNA912193 and SRA study SRP413071. Searching any of these in the dataset finder brings you back here.

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