Targeting postsynaptic glutamate receptor scaffolding proteins PSD-95 and PICK1 for obesity treatment
RNA-seq (gene expression) · mouse · 47 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 47 samples: 6 conditions, mostly with about 8 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Targeting postsynaptic glutamate receptor scaffolding proteins PSD-95 and PICK1 for obesity treatmentScience advances · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE221549_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA914766 and SRA study SRP414356. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 47 samples.
How we read this: 6 replicated groups read from 47 sample titles; they account for 47 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6883911 PFC, PICK1i, rep1 PFC, PICK1i,
- GSM6883912 PFC, PICK1i, rep2 PFC, PICK1i,
- GSM6883913 PFC, Saline, rep1 PFC, Saline,
- GSM6883914 PFC, Saline, rep2 PFC, Saline,
- GSM6883915 PFC, PICK1i, rep3 PFC, PICK1i,
- GSM6883916 PFC, PICK1i, rep4 PFC, PICK1i,
- GSM6883917 PFC, Saline, rep3 PFC, Saline,
- GSM6883918 PFC, Saline, rep4 PFC, Saline,
- GSM6883919 PFC, Saline, rep5 PFC, Saline,
- GSM6883920 PFC, Saline, rep6 PFC, Saline,
- GSM6883921 PFC, PSD-95i, rep1 PFC, PSD-95i,
- GSM6883922 PFC, PSD-95i, rep2 PFC, PSD-95i,
- GSM6883923 PFC, PICK1i, rep5 PFC, PICK1i,
- GSM6883924 PFC, PICK1i, rep6 PFC, PICK1i,
- GSM6883925 PFC, PSD-95i, rep3 PFC, PSD-95i,
- GSM6883926 PFC, PSD-95i, rep4 PFC, PSD-95i,
- GSM6883927 PFC, PSD-95i, rep5 PFC, PSD-95i,
- GSM6883928 PFC, PSD-95i, rep6 PFC, PSD-95i,
- GSM6883929 PFC, PICK1i, rep7 PFC, PICK1i,
- GSM6883930 PFC, PICK1i, rep8 PFC, PICK1i,
- GSM6883931 PFC, PSD-95i, rep7 PFC, PSD-95i,
- GSM6883932 PFC, PSD-95i, rep8 PFC, PSD-95i,
- GSM6883933 PFC, Saline, rep7 PFC, Saline,
- GSM6883934 PFC, Saline, rep8 PFC, Saline,
- GSM6883935 hippocampus, PICK1i, rep1 hippocampus, PICK1i,
- GSM6883936 hippocampus, PICK1i, rep2 hippocampus, PICK1i,
- GSM6883937 hippocampus, Saline, rep1 hippocampus, Saline,
- GSM6883938 hippocampus, PICK1i, rep3 hippocampus, PICK1i,
- GSM6883939 hippocampus, PICK1i, rep4 hippocampus, PICK1i,
- GSM6883940 hippocampus, Saline, rep2 hippocampus, Saline,
- GSM6883941 hippocampus, Saline, rep3 hippocampus, Saline,
- GSM6883942 hippocampus, Saline, rep4 hippocampus, Saline,
- GSM6883943 hippocampus, Saline, rep5 hippocampus, Saline,
- GSM6883944 hippocampus, PSD-95i, rep1 hippocampus, PSD-95i,
- GSM6883945 hippocampus, PSD-95i, rep2 hippocampus, PSD-95i,
- GSM6883946 hippocampus, PICK1i, rep5 hippocampus, PICK1i,
- GSM6883947 hippocampus, PICK1i, rep6 hippocampus, PICK1i,
- GSM6883948 hippocampus, PSD-95i, rep3 hippocampus, PSD-95i,
- GSM6883949 hippocampus, PSD-95i, rep4 hippocampus, PSD-95i,
- GSM6883950 hippocampus, PSD-95i, rep5 hippocampus, PSD-95i,
+ 7 more — browse all 47 samples with per-sample file links →
- GSE254269 BAI1 localises AMPA receptors at the cochlear afferent postsynaptic density and is 20 samples shares postsynaptic, receptor
- GSE261222 Scaffolding element rewires genome architecture during differentiation at the Zfp608 locus (RNA-Seq) 26 samples shares scaffolding
- GSE253629 Pre- and postsynaptic MEF2C promote experience-dependent, input-specific development of Layer 4 to Layer 2/3 excitatory synapses 12 samples shares postsynaptic
- GSE334783 The scaffolding protein AKAP79/150 shapes innate immune responses to allergen 12 samples shares scaffolding
- GSE341199 Hepatocyte RIPK1 scaffolding function protects against alcohol-induced liver injury by restraining ER stress-driven apoptosis and inflammation 8 samples shares scaffolding
- GSE240070 Functional analysis of membrane-associated scaffolding tight junction (TJ) proteins in tumorigenic characteristics of B16-F10 mouse melanoma cells. 3 samples shares scaffolding
- GSE262551 A Scaffolding Element Rewires Local 3D Chromatin Architecture During Differentiation 255 samples shares scaffolding
- GSE261221 Scaffolding element rewires genome architecture during differentiation at the Zfp608 locus (ChIP-Seq) 189 samples shares scaffolding
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.