Transcriptome sequencing of normal intestinal mucosal tissues, paired primary CRC tissues and liver metastases lesions in participants of CRC
RNA-seq (gene expression) · human · 52 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 52 samples: 20 × Group A vs 18 × Group B vs 14 × Group CGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Lipid deposition promotes YTHDF3-mediated m6A modification of PPARα to facilitate liver metastasis of colorectal cancerProtein & cell · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE221608_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA915076 and SRA study SRP414552. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 52 samples.
How we read this: 3 replicated groups read from 52 sample titles; they account for 52 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6890233 Group A-1 Group A
- GSM6890234 Group B-1 Group B
- GSM6890235 Group C-1 Group C
- GSM6890236 Group A-2 Group A
- GSM6890237 Group B-2 Group B
- GSM6890238 Group C-2 Group C
- GSM6890239 Group A-3 Group A
- GSM6890240 Group B-3 Group B
- GSM6890241 Group C-3 Group C
- GSM6890242 Group A-4 Group A
- GSM6890243 Group B-4 Group B
- GSM6890244 Group A-5 Group A
- GSM6890245 Group B-5 Group B
- GSM6890246 Group C-5 Group C
- GSM6890247 Group A-6 Group A
- GSM6890248 Group B-6 Group B
- GSM6890249 Group C-6 Group C
- GSM6890250 Group A-7 Group A
- GSM6890251 Group B-7 Group B
- GSM6890252 Group C-7 Group C
- GSM6890253 Group A-8 Group A
- GSM6890254 Group B-8 Group B
- GSM6890255 Group C-8 Group C
- GSM6890256 Group A-9 Group A
- GSM6890257 Group B-9 Group B
- GSM6890258 Group A-10 Group A
- GSM6890259 Group B-10 Group B
- GSM6890260 Group C-10 Group C
- GSM6890261 Group A-11 Group A
- GSM6890262 Group B-11 Group B
- GSM6890263 Group C-11 Group C
- GSM6890264 Group A-12 Group A
- GSM6890265 Group B-12 Group B
- GSM6890266 Group C-12 Group C
- GSM6890267 Group A-13 Group A
- GSM6890268 Group A-14 Group A
- GSM6890269 Group C-14 Group C
- GSM6890270 Group A-15 Group A
- GSM6890271 Group B-15 Group B
- GSM6890272 Group C-15 Group C
+ 12 more — browse all 52 samples with per-sample file links →
- GSE315534 Single-cell RNA sequencing of primary colorectal cancer, matched adjacent normal tissues, and paired liver metastases 15 samples shares metastases, primary, normal
- GSE256000 Open chromatin, HIF binding and mRNA expression analysis in primary tubule and ccRCC cells [RNA-seq] 32 samples shares crc, primary
- GSE255997 Open chromatin, HIF binding and mRNA expression analysis in primary tubule and ccRCC cells [ChIP-seq] 15 samples shares crc, primary
- GSE339157 Bulk RNA sequencing of prostate cancer (PCa) primary tumors and metastases: Epworth Clinical Cohort 48 samples shares metastases, primary
- GSE271259 RNAseq of human primary lung adenocarcinoma and brain metastases 40 samples shares metastases, primary
- GSE277212 Insights into intestinal neuroendocrine tumors in relation to normal human EEC differentiation [RNAseq] 27 samples shares intestinal, normal
- GSE298715 Primary human intestinal organoids recapitulate enteric infection of monkeypox virus and enable scalable drug discovery 18 samples shares intestinal, primary
- GSE277215 Insights into intestinal neuroendocrine tumors in relation to normal human EEC differentiation 53 samples shares intestinal, normal
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.