GEO series
Transcriptomic characterization of Paneth-derived and Intestinal stem cell-derived murine intestinal tumors
GSE221819
Mus musculus
Expression profiling by high throughput sequencing
15 samples
2024/03/27
GPL28457
Summary
To investigate the effect of the cell-of-origin on the transcriptional phenotype of the tumor, we performed bulk RNAseq on macroscopically dissected intestinal tumors from mice carrying lineage-specific Apc/Kras mutations in Paneth or ISC cells. Where indicated, tumorigenisis was triggered in an inflammatory context by administration of Dextran Sodium Sulfate (DSS).
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Paper (PMID 38902475) ↗
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