Liver transcriptomic response to partial hepatectomy in intestinal-specific SIRT1 knockout mice

Liver regeneration following partial hepatectomy (PHx) requires coordinated metabolic and inflammatory responses. Here, we investigated the contribution of intestinal SIRT1 to hepatic transcriptional reprogramming during early regeneration. Intestinal-specific SIRT1 knockout mice (SIRTintKO) and wild-type (WT) littermates were subjected to PHx, and liver tissue was collected at 6 h and 24 h post-surgery. Bulk RNA sequencing was performed to characterize genotype- and time-dependent transcriptional changes. This dataset provides insight into gut–liver axis regulation of early regenerative priming and metabolic adaptation.