Liver transcriptomic response to partial hepatectomy in intestinal-specific SIRT1 knockout mice
RNA-seq (gene expression) · mouse · 34 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 34 samples: 6 conditions, mostly with about 6 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Intestinal Sirtuin 1 Controls Liver Regeneration via Regulating the Intestinal Farnesoid X Receptor/Fibroblast Growth Factor 15 Axis in MiceCellular and molecular gastroenterology and hepatology · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE328885_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1456950 and SRA study SRP694192. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 34 samples.
How we read this: 6 replicated groups read from 34 sample titles; they account for 34 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9693399 SIRT1intKO liver 24 h post-PHx biological replicate 1 SIRT1intKO liver 24 h p…
- GSM9693400 SIRT1intKO liver 24 h post-PHx biological replicate 2 SIRT1intKO liver 24 h p…
- GSM9693401 SIRT1intKO liver 24 h post-PHx biological replicate 3 SIRT1intKO liver 24 h p…
- GSM9693402 SIRT1intKO liver 24 h post-PHx biological replicate 4 SIRT1intKO liver 24 h p…
- GSM9693403 WT liver 24 h post-PHx biological replicate 1 WT liver 24 h post-PHx
- GSM9693404 SIRT1intKO liver 6 h post-PHx biological replicate 1 SIRT1intKO liver 6 h po…
- GSM9693405 SIRT1intKO liver 6 h post-PHx biological replicate 2 SIRT1intKO liver 6 h po…
- GSM9693406 SIRT1intKO liver 6 h post-PHx biological replicate 3 SIRT1intKO liver 6 h po…
- GSM9693407 WT liver 6 h post-PHx biological replicate 1 WT liver 6 h post-PHx
- GSM9693408 SIRT1intKO liver 6 h post-PHx biological replicate 4 SIRT1intKO liver 6 h po…
- GSM9693409 WT liver 6 h post-PHx biological replicate 2 WT liver 6 h post-PHx
- GSM9693410 SIRT1intKO liver 6 h post-PHx biological replicate 5 SIRT1intKO liver 6 h po…
- GSM9693411 WT liver 6 h post-PHx biological replicate 3 WT liver 6 h post-PHx
- GSM9693412 WT liver 6 h post-PHx biological replicate 4 WT liver 6 h post-PHx
- GSM9693413 WT liver 6 h post-PHx biological replicate 5 WT liver 6 h post-PHx
- GSM9693414 WT liver 24 h post-PHx biological replicate 2 WT liver 24 h post-PHx
- GSM9693415 WT liver 24 h post-PHx biological replicate 3 WT liver 24 h post-PHx
- GSM9693416 SIRT1intKO liver 24 h post-PHx biological replicate 5 SIRT1intKO liver 24 h p…
- GSM9693417 WT liver 24 h post-PHx biological replicate 4 WT liver 24 h post-PHx
- GSM9693418 SIRT1intKO liver 24 h post-PHx biological replicate 6 SIRT1intKO liver 24 h p…
- GSM9693419 WT liver 6 h post-PHx biological replicate 6 WT liver 6 h post-PHx
- GSM9693420 SIRT1intKO liver 24 h post-PHx biological replicate 7 SIRT1intKO liver 24 h p…
- GSM9693421 WT liver untreated biological replicate 1 WT liver untreated
- GSM9693422 WT liver untreated biological replicate 2 WT liver untreated
- GSM9693423 WT liver untreated biological replicate 3 WT liver untreated
- GSM9693424 SIRT1intKO liver untreated biological replicate 1 SIRT1intKO liver untrea…
- GSM9693425 WT liver untreated biological replicate 4 WT liver untreated
- GSM9693426 WT liver untreated biological replicate 5 WT liver untreated
- GSM9693427 SIRT1intKO liver untreated biological replicate 2 SIRT1intKO liver untrea…
- GSM9693428 SIRT1intKO liver untreated biological replicate 3 SIRT1intKO liver untrea…
- GSM9693429 WT liver untreated biological replicate 6 WT liver untreated
- GSM9693430 SIRT1intKO liver untreated biological replicate 4 SIRT1intKO liver untrea…
- GSM9693431 SIRT1intKO liver untreated biological replicate 5 SIRT1intKO liver untrea…
- GSM9693432 SIRT1intKO liver untreated biological replicate 6 SIRT1intKO liver untrea…
- GSE282210 Transcriptome analysis of quiescent livers and regenerating livers after partial hepatectomy (PH) in young and aged mice 133 samples shares hepatectomy, partial, liver
- GSE256002 Comparison of transcriptional changes in regenerating mice livers at baseline and 24-48 hours post 70% partial hepatectomy with or without etomoxir treatment 27 samples shares hepatectomy, partial, liver
- GSE233516 DNA dioxygenase Tet2 regulates liver regeneration after partial hepatectomy. 18 samples shares hepatectomy, partial, liver
- GSE108449 Altas of gene expression in mice liver during liver regeneration process post 2/3 partial hepatectomy using RNA-seq 18 samples shares hepatectomy, partial, liver
- GSE298695 Mechanosensing by endothelial Piezo1 promotes liver regeneration after partial hepatectomy via ATF2-ID1-Wnt2 pathway 16 samples shares hepatectomy, partial, liver
- GSE296764 Transcriptional expression of SCN, liver and heart at CT0 and CT12 after central VIP knockout of Bmal1 76 samples shares knockout, liver
- GSE292193 RNA-Seq Reveals Enhanced Inflammation and Fibrosis in Alcohol-Induced Liver Injury of Apoe Knockout Mice 18 samples shares knockout, liver
- GSE315829 Investigate changes in gene expression and enriched pathways in endothelial cells following Liver endothelial Heg1 knockout. 13 samples shares knockout, liver
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.