Arsenite exposure disturbs maternal-to-zygote transition by attenuating H3K27ac during mouse preimplantation development
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 12 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × 2-cell embryo, 0um vs 3 × 2-cell embryo, 5um vs 2 × 2-cell embryo, H3K27ac, AS, vs 2 × 2-cell embryo, H3K27ac, CTR,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE222536_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA922478 and SRA study SRP416815. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 10 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 10 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6925676 2-cell embryo, H3K27ac, AS, rep1 2-cell embryo, H3K27ac,…
- GSM6925677 2-cell embryo, H3K27ac, AS, rep2 2-cell embryo, H3K27ac,…
- GSM6925678 2-cell embryo, AS, input
- GSM6925679 2-cell embryo, H3K27ac, CTR, rep1 2-cell embryo, H3K27ac,…
- GSM6925680 2-cell embryo, H3K27ac, CTR, rep2 2-cell embryo, H3K27ac,…
- GSM6925681 2-cell embryo, CTR, input
- GSM6925682 2-cell embryo, 0um-1 2-cell embryo, 0um
- GSM6925683 2-cell embryo, 0um-2 2-cell embryo, 0um
- GSM6925684 2-cell embryo, 0um-3 2-cell embryo, 0um
- GSM6925685 2-cell embryo, 5um-1 2-cell embryo, 5um
- GSM6925686 2-cell embryo, 5um-2 2-cell embryo, 5um
- GSM6925687 2-cell embryo, 5um-3 2-cell embryo, 5um
- GSE222535 Arsenite exposure disturbs maternal-to-zygote transition by attenuating H3K27ac during mouse preimplantation development [RNA-seq] 6 samples shares h3k27ac, maternal-to-zygote, preimplantation, attenuating, transition, arsenite, exposure, disturbs
- GSE222534 Arsenite exposure disturbs maternal-to-zygote transition by attenuating H3K27ac during mouse preimplantation development [ChIP-seq] 6 samples shares h3k27ac, maternal-to-zygote, preimplantation, attenuating, transition, arsenite, exposure, disturbs
- GSE332794 Epigenomic profiling of H3K27ac in mouse brain regions under morphine and LPS exposure 206 samples shares h3k27ac, exposure
- GSE190102 Ageing-Related Changes to H3K4me3, H3K27ac and H3K27me3 in Purified Mouse Neurons 43 samples shares h3k27ac
- GSE245442 Acetyl-CoA production by Mediator-bound 2-ketoacid dehydrogenases boosts de novo histone acetylation and is regulated by nitric oxide [Chipseq_H3K27ac_spikein] 36 samples shares h3k27ac
- GSE317929 Effect of intrauterine growth restriction on the H3K4me3, H3K9ac, H3K27ac and H3k9me3 histione modification of microglia in hippocampus 34 samples shares h3k27ac
- GSE24165 Histone H3K27ac separates active from poised enhancers and predicts developmental state 33 samples shares h3k27ac
- GSE276779 YAP-Driven Malignant Reprogramming of Oral Epithelial Stem Cells, CUT&TAG sequencing for YAP, H3K27ac, and H3K27me3 32 samples shares h3k27ac
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.