Enhanced activities of OCT4 and SOX2 facilitates epigenetic reprogramming by modulating cell cycle
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 460 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 460 samples: 11 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Enhanced Activities of OCT4 and SOX2 Promote Epigenetic Reprogramming by Shortening G1 PhaseAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE222746_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA923599 and SRA study SRP577725. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 380 samples.
How we read this: 11 replicated groups read from the first 400 of 460 sample titles; they account for 380 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6929634 ATAC-seq of total OSK reprogramming cells
- GSM6929635 ATAC-seq of mCherry positive cells of OSK reprogramming cells
- GSM6929636 ATAC-seq of mCherry/mCitrine double positive cells of OSK reprogramming cells
- GSM6929637 ATAC-seq of mCitrine positive cells of OSK reprogramming cells
- GSM6929638 ATAC-seq of total OvSvK reprogramming cells
- GSM6929639 ATAC-seq of mCherry positive cells of OvSvK reprogramming cells
- GSM6929640 ATAC-seq of mCherry/mCitrine double positive cells of OvSvK reprogramming cells
- GSM6929641 ATAC-seq of mCitrine positive cells of OvSvK reprogramming cells
- GSM6929649 OSK CUT&Tag seq of H3K4me3
- GSM6929650 OSK CUT&Tag seq of H3K9me3
- GSM6929651 OSK CUT&Tag seq of H3K27me3
- GSM6929652 OSK CUT&Tag seq of H3K36me3
- GSM6929653 OvSvK CUT&Tag seq of H3K4me3
- GSM6929654 OvSvK CUT&Tag seq of H3K9me3
- GSM6929655 OvSvK CUT&Tag seq of H3K27me3
- GSM6929656 OvSvK CUT&Tag seq of H3K36me3
- GSM6929657 OSK+Flag+siNC CUT&Tag seq of H3K4me3
- GSM6929658 OSK+Ccne1+siCcnd1+siCdkn2a CUT&Tag seq of H3K4me3
- GSM6929659 OSK+Flag+siNC CUT&Tag seq of H3K27me3
- GSM6929660 OSK+Ccne1+siCcnd1+siCdkn2a CUT&Tag seq of H3K27me3
- GSM6929661 O Bulk RNA-seq rep1 O Bulk RNA-seq
- GSM6929662 O Bulk RNA-seq rep2 O Bulk RNA-seq
- GSM6929663 S Bulk RNA-seq rep1 S Bulk RNA-seq
- GSM6929664 S Bulk RNA-seq rep2 S Bulk RNA-seq
- GSM6929665 K Bulk RNA-seq rep1 K Bulk RNA-seq
- GSM6929666 K Bulk RNA-seq rep2 K Bulk RNA-seq
- GSM6929667 OS Bulk RNA-seq rep1 OS Bulk RNA-seq
- GSM6929668 OS Bulk RNA-seq rep2 OS Bulk RNA-seq
- GSM6929669 SK Bulk RNA-seq rep1 SK Bulk RNA-seq
- GSM6929670 SK Bulk RNA-seq rep2 SK Bulk RNA-seq
- GSM6929671 OK Bulk RNA-seq rep1 OK Bulk RNA-seq
- GSM6929672 OK Bulk RNA-seq rep2 OK Bulk RNA-seq
- GSM6930132 Single-cell RNA-seq day0 cell1 Single-cell RNA-seq day…
- GSM6930133 Single-cell RNA-seq day0 cell2 Single-cell RNA-seq day…
- GSM6930134 Single-cell RNA-seq day0 cell3 Single-cell RNA-seq day…
- GSM6930135 Single-cell RNA-seq day0 cell4 Single-cell RNA-seq day…
- GSM6930136 Single-cell RNA-seq day0 cell5 Single-cell RNA-seq day…
- GSM6930137 Single-cell RNA-seq day0 cell6 Single-cell RNA-seq day…
- GSM6930138 Single-cell RNA-seq day0 cell7 Single-cell RNA-seq day…
- GSM6930139 Single-cell RNA-seq day0 cell8 Single-cell RNA-seq day…
+ 420 more — browse all 460 samples with per-sample file links →
- GSE222745 Enhanced activities of OCT4 and SOX2 facilitates epigenetic reprogramming by modulating cell cycle [scRNA-Seq] 422 samples shares oct4, sox2, reprogramming, facilitates, activities, epigenetic, modulating, enhanced
- GSE294288 Enhanced activities of OCT4 and SOX2 facilitates epigenetic reprogramming by modulating cell cycle [OSK/OvSvK CUT&TAG] 11 samples shares oct4, sox2, reprogramming, facilitates, activities, epigenetic, modulating, enhanced
- GSE264614 Emerging cooperativity between Oct4 and Sox2 governs the pluripotency network in mouse early embryos [ATAC-seq] 44 samples shares oct4, sox2
- GSE294258 Intracellular iron homeostasis-regulated epigenetic reprogramming contributes to -7/del(7q) leukemia 71 samples shares reprogramming, epigenetic
- GSE286574 Intrauterine hyperglycemia impairs primordial germ cell development and fertility by sex-specific epigenetic reprogramming interference in mice offspring [ATAC-seq] 30 samples shares reprogramming, epigenetic
- GSE270509 In vivo CRISPR screen reveals interplay of epigenetic regulators underlies kinetics of hepatobiliary reprogramming [RNA-Seq] 27 samples shares reprogramming, epigenetic
- GSE319246 ApoE4 Drives Microglial Lipid Dysregulation in Alzheimer’s Disease via Epigenetic Reprogramming of the AsxL1/LXRα–H3K4me3 Axis 24 samples shares reprogramming, epigenetic
- GSE99296 α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming 18 samples shares reprogramming, epigenetic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.