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Endogenous viral elements constitute a complementary source of antigens for personalized cancer immunotherapy

GSE223515 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/03/26 Platform GPL24247
Summary
We present a pipeline, ObsERV, for the design of personalized cancer immunotherapies based on epitopes derived from endogenous retroviral elements (EVEs). We show that EVE-derived peptides are presented as antigens on tumors and can be predicted by ObsERV. Preclinical testing of ObsERV demonstrates elicitation of poly-functional CD4+ and CD8+ T-cell responses as well as long-term tumor protection and persistence of the responses.
Published in
Endogenous viral elements constitute a complementary source of antigens for personalized cancer vaccines
Garde C, Pavlidis MA, Garces P et al. · NPJ vaccines 2025 · PMID 40113807 · doi:10.1038/s41541-025-01107-y
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Also filed as BioProject PRJNA926630 and SRA study SRP418738. Searching any of these in the dataset finder brings you back here.

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