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High throughput sequencing of small cell lung cancer chemosensitive H69 and corresponding chemoresistant H69AR

GSE223949 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/01/28 Platform GPL11154
Summary
Small cell lung cancer (SCLC) is the most aggressive subtype of lung cancer. Although most patients are initially sensitive to first-line chemotherapy with combined cisplatin and etoposide, chemotherapy drugs resistance easily develops and quickly leads to tumor progression. Therefore, understanding mechanisms of chemotherapy drugs resistance and how to reverse it is key to improving the prognosis of patients with SCLC. The parental SCLC cell lines H69 and corresponding doxorubicin-induced multidrug resistant variant (H69AR) were used to explore the mechanism of chemoresistance in SCLC.
Published in
KDM4B/DHX9 promotes chemoresistance in small-cell lung cancer through the MYCN-driven signaling pathway
Lyu Q, Liu H, Shen W et al. · Oncogene 2026 · PMID 42056557 · doi:10.1038/s41388-026-03798-6
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Also filed as BioProject PRJNA929197 and SRA study SRP419915. Searching any of these in the dataset finder brings you back here.

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