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Macrophage epigenetic memories of early life injury drive neonatal nociceptive priming. [ATAC-Seq]

GSE224207 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 9 samples Submitted 2024/04/22 Platform GPL24247
Summary
The developing peripheral nervous and immune systems are functionally distinct from adults. These systems are vulnerable to effects of early life injury which can influence outcomes related to nociception following subsequent injury later in life (i.e. “neonatal nociceptive priming”). The underpinnings of this phenomenon are largely unknown, although critical periods in macrophages can be epigenetically trained by injury. We found that macrophages are both necessary and partially sufficient to drive neonatal nociceptive priming possibly due to a long-lasting epigenetic remodeling of peripheral macrophages. The p75 neurotrophic factor receptor (NTR) was found to be an important effector in regulating this “nociceptive trained immunity”. p75NTR modulates the inflammatory profile and responses of rodent and human macrophages and this “pain memory” was able to be transferred to a naive host to alter sex-specific pain-related behaviors. This study reveals a novel mechanism by which acute post-surgical pain may transition to chronic pain in children.
Published in
Macrophage memories of early-life injury drive neonatal nociceptive priming
Dourson AJ, Fadaka AO, Warshak AM et al. · Cell reports 2024 · PMID 38640063 · doi:10.1016/j.celrep.2024.114129
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Also filed as BioProject PRJNA930318 and SRA study SRP420401. Searching any of these in the dataset finder brings you back here.

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