H3K27ac ChIP-seq and RNA-seq of papillary thyroid carcinoma patient's tissues and paired normal tissues
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 12 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Topic
- Thyroid cancerThis series is part of our curated briefing on it.
- Samples
- 12 samples: 6 × Normal tissue vs 6 × Tumor tissueGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Enhancer-mediated NR2F2 recruitment activates BGN to promote tumor growth and shape tumor microenvironment in papillary thyroid cancerTheranostics · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE224357_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA930701 and SRA study SRP420645. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 6 samples read as cases, 6 as controls.
How we read this: 2 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7020406 Normal tissue_1 Normal tissue
- GSM7020407 Tumor tissue_1 Tumor tissue
- GSM7020408 Normal tissue_2 Normal tissue
- GSM7020409 Tumor tissue_2 Tumor tissue
- GSM7020410 Normal tissue_3 Normal tissue
- GSM7020411 Tumor tissue_3 Tumor tissue
- GSM7020412 Normal tissue_1 Normal tissue
- GSM7020413 Tumor tissue_1 Tumor tissue
- GSM7020414 Normal tissue_2 Normal tissue
- GSM7020415 Tumor tissue_2 Tumor tissue
- GSM7020416 Normal tissue_3 Normal tissue
- GSM7020417 Tumor tissue_3 Tumor tissue
- GSE241184 Single cell profiling of primary and paired metastatic lymph node tumors and adjacent normal thyroid in a papillary thyroid carcinoma patient 3 samples same disease briefing · shares papillary, thyroid, paired, normal
- GSE33630 Normal thyrocytes vs papillary vs anaplastic thyroid carcinomas 105 samples same disease briefing · shares papillary, thyroid, normal
- GSE165724 Transcriptome analysis discloses dysregulated genes in normal appearing tumor-adjacent thyroid tissues from patients with papillary thyroid carcinoma 74 samples same disease briefing · shares papillary, thyroid, normal
- GSE138198 Differentially expression profiling in Hashimoto's thyroiditis (HT), papillary thyroid carcinoma (PTC) with HT in background, PTC without HT in background, micro PTC (mPTC), and three normal thyroid samples (TN). 36 samples same disease briefing · shares papillary, thyroid, normal
- GSE212031 Next Generation translatome Sequencing (Ribo-seq) of Papillary Thyroid Carcinoma tissue sample and adjacent normal tissue 8 samples same disease briefing · shares papillary, thyroid, normal
- GSE191288 Dissecting the transcriptomic landscape of the human papillary thyroid carcinoma by single cell RNA-sequencing 7 samples same disease briefing · shares papillary, rna-seq, thyroid
- GSE310793 PRECISE: A prognostic thyroid follicular-cell derived gene signature for papillary thyroid carcinoma 109 samples same disease briefing · shares papillary, thyroid
- GSE317520 Mitochondrial DNA Mutations Drive Tumor Heterogeneity in Papillary Thyroid Carcinoma 92 samples same disease briefing · shares papillary, thyroid
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.