GEO series
CMPD1 is a microtubule inhibitor with tumor-specific cytotoxicity
GSE224462
Homo sapiens
Expression profiling by high throughput sequencing
18 samples
2024/12/31
GPL24676GPL18573
Summary
Microtubule-targeting agents have been widely used for cancer treatment, yet their cancer specificity is a common challenge. In this study, we identified that CMPD1 as a promising cancer specific inhibitor. Both in vitro and in vivo experiments showed that CMPD1 efficiently inhibits tumor growth. Mechanistically, CMPD1 inhibits microtubule polymerization in mitosis. Collectively, CMPD1 has the high potential to serve as a cancer cell inhibitor.
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Paper (PMID 40439108) ↗
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