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Transcriptomic analysis of spinal cord microglial cells from NTg and ATXN2-Q33;TDP-43 adult mice

GSE224581 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/07/16 Platform GPL21103
Summary
Intermediate-length repeat expansions in ATAXIN-2 (ATXN2) are a strong genetic risk factor for amyotrophic lateral sclerosis (ALS). At the molecular level, ATXN2 intermediate expansions enhance TDP-43 toxicity and pathology. However, whether this triggers ALS pathogenesis at the cellular and functional level remains unknown. Our study shows that microglial cells might contribute to ALS-related pathology observed in mice carrying ATXN2 intermediate repeat expansions (Q33) in an ALS background (TDP-43). To investigate whether ATXN2-Q33;TDP-43 spinal cord microglia are transcriptomically different from non transgenic counterparts, we performed RNA sequencing of sorted microglial cells from knock-in (ATXN2-Q33;TDP-43) as well as non-transgenic (NTg) mice.
Published in
ATAXIN-2 intermediate-length polyglutamine expansions elicit ALS-associated metabolic and immune phenotypes
Vieira de Sá R, Sudria-Lopez E, Cañizares Luna M et al. · Nature communications 2024 · PMID 39209824 · doi:10.1038/s41467-024-51676-0
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Also filed as BioProject PRJNA934453 and SRA study SRP424176. Searching any of these in the dataset finder brings you back here.

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